Anterior brain deficits in chronic alcoholism - Cause or effect?
Anterior brain deficits in chronic alcoholism - Cause or effect?
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DOI：
10.1097/00005053-199512000-00005
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发表时间：
1995-12-01
影响因子：
1.9
通讯作者：
Jung, RE
中科院分区：
文献类型：
--
作者：
Ciesielski, KT;Waldorf, AV;Jung, RE
为了研究前脑参与酒精中毒的假设，使用通常与额叶功能相关的神经心理学测试对非家族性短期饮酒者（STD）和长期饮酒者（LTD）进行了评估。 STD 和 LTD 在视觉介导的概念形成和思维灵活性方面均受到类似损害。与 STD 组相比，LTD 组的其他时间限制测试（需要良好的注意力和即时记忆、视觉扫描和视觉运动协调能力）的结果显着较低。这些数据提出了酒精中毒中前脑功能障碍的双因素假设：概念性思维的先前存在缺陷和随之而来的中枢神经系统异常（精神运动减慢、注意力下降和即时记忆）与长期饮酒相关，并且类似于过早衰老的迹象。
To investigate the hypothesis of anterior brain involvement in alcoholism, nonfamilial short-term drinkers (STD) and long-term drinkers (LTD) were assessed using neuropsychological tests commonly related to frontal lobe functions. Both STDs and LTDs were similarly impaired on measures of visually mediated concept formation and flexibility of thinking. Results from other time-constrained tests that required good concentration and immediate memory, visual scanning, and visual-motor coordination were significantly lower in the LTD group as compared with STDs. The data suggest a dual-factor hypothesis of anterior cerebral dysfunctions in alcoholism: a preexisting deficit in conceptual thinking and consequential CNS abnormality (psychomotor slowing, decreased attentiveness, and immediate memory) associated with prolonged alcohol intake, and resembling signs of premature aging.