Cohort Profile: The Mexican American Mano a Mano Cohort
Cohort Profile: The Mexican American Mano a Mano Cohort
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DOI：
10.1093/ije/dyv016
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发表时间：
2017-04-01
影响因子：
7.7
通讯作者：
Wu, Xifeng
中科院分区：
文献类型：
--
作者：
Chow, Wong-Ho;Chrisman, Matthew;Wu, Xifeng
西班牙裔美国人是美国人口最多、增长最快的少数民族。在德克萨斯州的休斯顿，44%的人口是西班牙裔，其中大多数是墨西哥裔美国人（78%）。这一人群在健康相关研究中的代表性不足，尽管他们的肥胖和糖尿病患病率很高，这可能使他们易患癌症和其他慢性疾病。认识到有必要对西班牙裔美国人的健康风险进行更大的研究，以人口为基础的墨西哥裔美国人（Mano a Mano）队列研究于2001年启动。这是一个开放队列，招募将持续到2019年，截至2014年6月30日，来自16600多个家庭的23606名成人参与者被招募。双语采访者会亲自询问人口统计、文化适应、生活方式、职业、病史、家族癌症史、自我报告和测量的身高和体重，以及其他暴露情况。在基线时分别收集了43%、56%和63%的参与者的尿液、血液和唾液样本。大约90%的参与者可以获得DNA样本。通过每年一次的电话联系以及与德州癌症登记处和/或医疗记录的联系，确定癌症和其他慢性疾病的发病率。分子数据，如遗传祖先标记，血液端粒长度和糖化血红蛋白（葡萄糖耐量受损的标志），可用于相当比例的参与者。数据访问可根据要求提供[nrianoannano@mdanderson.org]。更多信息请访问[www.mano-mano.us]。
Hispanic Americans comprise the largest and fastest-growing ethnic minority in the USA. In Houston, Texas, 44% of the population is of Hispanic descent, with the majority being Mexican Americans (78%). This population is under-represented in health-related research despite their high prevalence of obesity and diabetes, which may predispose them to cancer and other chronic conditions. Recognizing the need for a greater research effort into the health risks of Hispanic Americans, the population-based Mexican American (Mano a Mano) Cohort study was launched in 2001. This is an open cohort with enrolment ongoing to 2019, and as of 30 June 2014, 23 606 adult participants from over 16 600 households were enrolled. Bilingual interviewers elicit information in person on demographics, acculturation, lifestyle, occupation, medical history, family cancer history, self-reported and measured height and weight, and other exposures. Urine, blood and saliva samples have been collected at baseline from 43%, 56% and 63% of participants, respectively. DNA samples are available for about 90% of participants. Incident cancers and other chronic diseases are ascertained through annual telephone re-contact and linkage to the Texas Cancer Registry and/or medical records. Molecular data such as genetic ancestry markers, blood telomere length and HbA1c, a marker of impaired glucose tolerance, are available for a substantial proportion of the participants. Data access is provided on request [nrianoannano@mdanderson.org]. For further information please visit [www.mano-mano.us].