mTOR and the control of whole body metabolism

mTOR and the control of whole body metabolism
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DOI:
10.1016/j.ceb.2009.01.024
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发表时间:
2009-04-01
影响因子:
7.5
通讯作者:
Hall, Michael N.
Hall, Michael N.
中科院分区:
生物学2区
文献类型:
--
作者:
Polak, Pazit;Hall, Michael N.

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哺乳动物雷帕霉素靶蛋白(mTOR)是一种高度保守的蛋白激酶,作为两种不同的多蛋白复合物的一部分发挥作用,以调节生长和代谢。本文综述了mTOR信号转导领域最重要的最新进展。此外,我们还对mTOR在不同器官中的功能进行了概述,特别关注mTOR在全身能量代谢中的作用。
Mammalian Target of Rapamycin (mTOR) is a highly conserved protein kinase that functions as part of two distinct multiprotein complexes to regulate growth and metabolism. This review describes the most important recent advances in the mTOR signaling field. In addition, we provide an overview on the functions of mTOR in different organs, with a special focus on the role of mTOR in whole body energy metabolism.