Biochemical and Molecular Roles of Nutrients Dietary Maltitol Decreases the Incidence of 1,2-Dimethylhydrazine-Induced Cecum and Proximal Colon Tumors in Rats
Biochemical and Molecular Roles of Nutrients Dietary Maltitol Decreases the Incidence of 1,2-Dimethylhydrazine-Induced Cecum and Proximal Colon Tumors in Rats
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营养素膳食麦芽糖醇的生化和分子作用可降低 1,2-二甲基肼诱发的大鼠盲肠和近端结肠肿瘤的发病率
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发表时间：
1998
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通讯作者：
Y. Shimomura
中科院分区：
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作者：
Midoriko Tsukamura;H. Goto;T. Arisawa;Tetsuo Hayakawa;N. Nakai;T. Murakami;Noriaki Fujitsuka;Y. Shimomura
麦芽糖醇在结肠中发酵，因为在小肠中只有部分水解。在本研究中，我们研究了膳食麦芽糖醇对二甲肼诱导的大鼠肠道肿瘤的影响。实验1：饲喂无纤维饲粮或在饲粮中添加1或5 g/100 g麦芽糖醇27周。实验前14周，各组大鼠分别单独注射二甲肼或二甲基肼。在二甲肼处理的大鼠中，添加1 g/100 g麦芽糖醇可显著降低盲肠肿瘤发生率，添加5%麦芽糖醇可降低盲肠和近端结肠肿瘤发生率。在实验2中，我们研究了1 g/100 g麦芽糖醇饮食对安慰剂和二甲肼治疗大鼠盲肠内容物中短链脂肪酸浓度的影响。饲粮添加1 g/100 g麦芽糖醇可使丁酸盐浓度增加一倍（P õ 0.05），但对盲肠内容物中醋酸盐和丙酸盐没有影响。上述结果提示，膳食麦芽糖醇对二甲肼诱导的大鼠盲肠和近端结肠肿瘤具有保护作用，盲肠细菌发酵麦芽糖醇产生的丁酸盐可能参与了这一保护作用。中华医学杂志。28(3):536-540,1998。
Maltitol is fermented in the colon due to only partial hydrolysis in the small intestine. In the present study, we examined effects of dietary maltitol on dimethylhydrazine-induced intestinal tumor in rats. In experiment 1, rats were fed a fiber-free diet or diets supplemented with 1 or 5 g/100 g maltitol for 27 wk. Each group of rats was injected with dimethylhydrazine or vehicle alone for the first 14 wk of the experimental period. Maltitol supplementation at 1 g/100 g of the diet significantly reduced tumor incidence in the cecum and the 5% supplement reduced tumor incidence in both the cecum and proximal colon in dimethylhydrazine-treated rats. In experiment 2, we investigated the effect of the 1 g/100 g maltitol diet on the short chain fatty acid concentrations in cecal contents of placebo and dimethylhydrazine-treated rats. Intake of the 1 g/100 g maltitol diet doubled (P õ 0.05) the concentration of butyrate but did not affect acetate or propionate in the cecal contents. These results suggest that dietary maltitol has a protective effect against dimethylhydrazine-induced tumors in rat cecum and proximal colon and that butyrate produced by bacterial fermentation of maltitol in the cecum may be involved in the protection. J. Nutr. 128: 536–540, 1998.