The development of the atrioventricular junction in the human heart.
The development of the atrioventricular junction in the human heart.
复制标题
人类心脏房室交界处的发育。
DOI：
10.1161/01.res.78.1.110
复制
发表时间：
1996
影响因子：
20.1
通讯作者：
W. Lamers
中科院分区：
文献类型：
--
作者：
A. Wessels;Marry W. M. Markman;J. Vermeulen;R. Anderson;A. Moorman;W. Lamers
通过使用特异于房室垫组织、间充质细胞、心房和心室心肌以及初级环心肌的单克隆抗体，通过免疫组织化学方法研究了发育中的人类心脏中房室交界处心房和心室心肌之间分离的组织发生。研究发现，心房和心室肌肉块之间的绝缘是通过房室沟（位于交界心肌的心外膜侧）与房室垫（位于交界心肌的心内膜侧）组织的融合而建立的。这个过程发生在房室管心肌的心室边缘。心房和心室心肌的分离在右房室交界处前内侧部分约发育 7 周时开始，并在发育第 12 周左右基本完成。心房和心室心肌之间唯一剩余的心肌连续性是房室传导轴。我们的研究结果表明，房室瓣发育中的小叶的非肌肉部分源自房室垫，并且房室沟的组织对这些小叶的发育没有贡献。
The histogenesis of the separation between atrial and ventricular myocardium at the atrioventricular junction in the developing human heart has been investigated immunohistochemically by using monoclonal antibodies specific for atrioventricular cushion tissue, mesenchymal cells, atrial and ventricular myocardium, and myocardium of the primary ring. It was found that the insulation between the muscle masses of atrium and ventricle is established by the fusion of the tissues of the atrioventricular sulcus (located at the epicardial side of the junctional myocardium) with those of the atrioventricular cushions (located at the endocardial side of the junctional myocardium). This process takes place at the ventricular margin of the myocardium of the atrioventricular canal. The separation of atrial and ventricular myocardium starts at approximately 7 weeks of development in the anteromedial portion of the right atrioventricular junction and is largely completed around the 12th week of development. The only remaining myocardial continuity between atrial and ventricular myocardium is the atrioventricular axis of conduction. Our findings show that the nonmuscular part of the developing leaflets of the atrioventricular valves derives from the atrioventricular cushions and that the tissues of the atrioventricular groove do not contribute to the development of these leaflets.