Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary.
Macrophage-derived multinucleated giant cells: hallmarks of the aging ovary.
复制标题
巨噬细胞衍生的多核巨细胞：卵巢衰老的标志。
DOI：
10.1530/rep-20-0489
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Duncan FE
中科院分区：
文献类型：
--
作者：
Foley KG;Pritchard MT;Duncan FE
Inflammaging is a state of chronic, low grade inflammation associated with biological aging which contributes to age-related diseases. Recently, an age-associated increase in inflammation has been documented in the mammalian ovary, which is accompanied by a shift in the immune cell profile. In this Point of View article, we consider a unique population of macrophage-derived multinucleated giant cells, found in reproductively old mouse ovaries, as potential markers or functional drivers of inflammation in ovarian aging.
