Surfing biological surfaces: exploiting the nucleoid for partition and transport in bacteria.
Surfing biological surfaces: exploiting the nucleoid for partition and transport in bacteria.
复制标题
冲浪生物表面：利用类核在细菌中进行分配和运输。
DOI：
10.1111/mmi.12017
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发表时间：
2012
影响因子：
3.6
通讯作者：
Funnell,BarbaraE
中科院分区：
文献类型：
--
作者：
Vecchiarelli,AnthonyG;Mizuuchi,Kiyoshi;Funnell,BarbaraE
PARA家族的ATPase负责运输细菌的染色体、质粒和大型蛋白质机器。Paras在体内形成了类核素的模式，但模式如何在运输中发挥作用或被利用仍有相当大的争议。在这里，我们讨论了细菌类核上的自组织成模式的过程，并探索了它如何与对位作用的分子机制有关。我们回顾了准介导的DNA分配是如何在生物表面上由ATP驱动的蛋白质梯度如何导致中尺度上的空间组织的一般机制。我们还讨论了类核如何作为细胞中大型物体的强大扩散障碍，并提出Para家族通过利用类核作为移动的基质来克服这一障碍的情况。
The ParA family of ATPases is responsible for transporting bacterial chromosomes, plasmids and large protein machineries. ParAs pattern the nucleoidin vivo, but how patterning functions or is exploited in transport is of considerable debate. Here we discuss the process of self‐organization into patterns on the bacterial nucleoid and explore how it relates to the molecular mechanism of ParA action. We review ParA‐mediated DNA partition as a general mechanism of how ATP‐driven protein gradients on biological surfaces can result in spatial organization on a mesoscale. We also discuss how the nucleoid acts as a formidable diffusion barrier for large bodies in the cell, and make the case that the ParA family evolved to overcome the barrier by exploiting the nucleoid as a matrix for movement.