Effect of hydrodynamic forces on virus removal capability of Planova™ filters
Effect of hydrodynamic forces on virus removal capability of Planova™ filters
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DOI：
10.1002/aic.14392
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发表时间：
2014-06-01
期刊：
影响因子：
3.7
通讯作者：
Nagoya, Fujiharu
中科院分区：
文献类型：
--
作者：
Yamamoto, Aguru;Hongo-Hirasaki, Tomoko;Nagoya, Fujiharu
病毒去除过程对于生物产品安全极其重要。这项研究详细描述了 Planova (TM) 过滤器的病毒去除机制。这些包括以下内容：(1) 机制 1：尺寸排阻，(2) 机制 2：水动力约束，以及 (3) 机制 3：多步过滤。通过模拟和实验，从病毒运动的动态角度研究了该过程。我们的结果表明，机制 2 和布朗运动是基于尺寸排阻的过滤去除病毒的关键因素，可以通过佩克莱特数进行评估。动态视角的加入使得描述宏观现象成为可能，例如过滤压力和溶液粘度对病毒去除能力的影响。 (c) 2014 美国化学工程师学会 AIChE J, 60: 2286-2297, 2014
Virus removal processes are extremely important to biological product safety. This study gives a detailed description of the virus removal mechanisms of Planova (TM) filters. These include the following: (1) Mechanism 1: size exclusion, (2) Mechanism 2: constraint by hydrodynamic forces, and (3) Mechanism 3: multistep filtration. The process was studied through the dynamic perspective of virus movement using simulations and experiments. Our results show that Mechanism 2 and Brownian motion are key factors in virus removal of size exclusion-based filtration and can be evaluated by Peclet number. The addition of dynamic perspective makes it possible to describe macroscopic phenomena such as the effects of filtration pressure and solution viscosity on virus removal capabilities. (c) 2014 American Institute of Chemical Engineers AIChE J, 60: 2286-2297, 2014