Bacterial adhesion on titanium nitride-coated and uncoated implants: an in vivo human study.
Bacterial adhesion on titanium nitride-coated and uncoated implants: an in vivo human study.
复制标题
DOI：
10.1563/1548-1336(2003)029
复制
发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Piattelli, Adriano
中科院分区：
文献类型：
--
作者：
Scarano, Antonio;Piattelli, Maurizio;Piattelli, Adriano
氮化钛（TiN）已在许多领域中用作外科手术器械涂层，使外科手术材料更耐磨损和腐蚀。本研究的目的是在体内评价细菌对TiN涂层（试验）和未涂层（对照）钛植入物的粘附。6名年龄在21至25岁之间且全身健康状况良好的患者参与了本研究。所有参与者都表示知情同意。参与者是根据良好的牙周健康和没有口呼吸的迹象来选择的。在6名参与者中的每一个中，将可移除的丙烯酸装置适配到颌骨的每个象限的磨牙-前磨牙区域。将一个4 x 13 mm钛种植体粘在每个器械的颊侧。等离子喷涂覆盖了11.5 mm的种植体主体，而颈部为机加工钛。试验植入物与右侧器械粘合，对照植入物与左侧器械粘合。24小时后，将植入物从每个器械中取出，并进行扫描电子显微镜检查，以评价被细菌覆盖的植入物机械加工部分。本研究共使用了24个种植体，12个试验种植体和12个对照种植体。对另外10个植入物（5个试验植入物和5个对照植入物）进行了植入物颈部机加工部分的表面表征。与对照种植体相比，受试种植体表面被细菌覆盖的数量显著降低（P = .0001）。两组的表面粗糙度相似。TiN表面显示出细菌存在的显著减少，并且这一事实可能在减少种植体周围软组织的炎症方面是重要的。
Titanium nitride (TiN) has been used in many fields as a surgical instrument coating that makes the surgical materials more resistant to wear and corrosion. The aim of the present study was an in vivo evaluation of the bacterial adhesion to TiN-coated (test) and uncoated (control) titanium implants. Six patients aged between 21 and 25 years and in excellent systemic health participated in the study. All of the participants gave their informed consent. The participants were selected on the basis of good periodontal health and no signs of mouth breathing. In each of the 6 participants, a removable acrylic device was adapted to the molar-premolar region of each quadrant of the jaws. One 4 x 13 mm titanium implant was glued to the buccal aspect of each device. The plasma spray covered 11.5 mm of the body of the implant, whereas the neck was machined titanium. Test implants were glued to the right devices and control implants were glued to the left devices. After 24 hours, the implants were removed from each device and processed for scanning electron microscopy for evaluation of the machined portion of the implant covered by bacteria. A total of 24 implants were used in this study, 12 test and 12 control. Surface characterization of the machined portion of the neck of the implant was performed on an additional 10 implants (5 test and 5 control). On test implants the implant surface covered by bacteria was significantly lower compared with that of control implants (P = .0001). The surface roughness was similar in both groups. TiN surfaces showed a significant reduction of the presence of bacteria, and this fact could probably be important in the decrease of the inflammation of the peri-implant soft tissues.