Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy
Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy
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DOI：
10.1093/ajcn/82.5.1040
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发表时间：
2005-11-01
影响因子：
7.1
通讯作者：
Shulman, RJ
中科院分区：
文献类型：
--
作者：
Galpin, L;Manary, MJ;Shulman, RJ
背景资料：热带肠病是一种无症状的小肠绒毛萎缩，在发展中国家普遍存在，并与肠道功能和完整性改变有关。热带肠病的组织学类似于小肠细菌过度生长中所见的。Objective：本研究验证了一个假设，即用益生菌Lactobacillus GG治疗3-5岁的马拉维儿童将改善他们的肠道功能和integrity.Design：临床健康儿童（n = 164）参加了一项安慰剂对照，随机，双盲试验。在用乳酸杆菌GG或安慰剂治疗30 d之前和之后，通过使用位点特异性糖吸收试验来测量肠功能和完整性。主要结果是尿乳果糖与甘露醇的比值（L：M）和尿蔗糖与乳果糖的比值（S：L）。结果：在完成研究的161名儿童中，119名（73%）在入组时患有热带肠病（L：M > 0.10）。接受乳酸菌GG的儿童在排泄方面与安慰剂组没有显著差异甘露醇（以给药剂量的%计）（（x）超过条形图+/- SD：分别为8.9 +/- 4.4和8.9 +/- 3.9），乳果糖（分别为0.31 +/-0.20和0.33 +/-0.23）或蔗糖（分别为0.078 +/-0.058和0.082 +/-0.075）。L：M和S：L在乳酸菌组和安慰剂组之间也没有显著差异（L：M分别为0.19 +/- 0.13和0.20 +/- 0.12; S：L分别为0.58 +/- 0.46和0.65 +/- 0.57）。
Background: Tropical enteropathy is an asymptomatic villous atrophy of the small bowel that is prevalent in the developing world and is associated with altered intestinal function and integrity. The histology of tropical enteropathy resembles that seen in small-bowel bacterial overgrowth.Objective: This study tested the hypothesis that treatment of 3-5-y-old Malawian children with the probiotic Lactobacillus GG would improve their intestinal function and integrity.Design: Clinically healthy children (n = 164) were enrolled in a placebo-controlled, randomized, double-blind trial. Intestinal function and integrity were measured by using the site-specific sugar-absorption test before and after 30 d of treatment with Lactobacillus GG or placebo. The primary outcomes were the ratios of urinary lactulose to mannitol (L:M) and of urinary sucrose to lactulose (S:L) excretion.Results: Of the 161 children who completed the study, 119 (73%) had tropical enteropathy on enrollment (L:M > 0.10). Children receiving Lactobacillus GG did not differ significantly from the placebo group in the excretion (in % of dose administered) of mannitol ((x) over bar +/- SD: 8.9 +/- 4.4 and 8.9 +/- 3.9, respectively), lactulose (0.31 +/- 0.20 and 0.33 +/- 0.23, respectively), or sucrose (0.078 +/- 0.058 and 0.082 +/- 0.075, respectively). L:M and S:L also did not differ significantly between the Lactobacillus and placebo groups (0.19 +/- 0.13 and 0.20 +/- 0.12, respectively, for L:M; 0.58 +/- 0.46 and 0.65 +/- 0.57, respectively, for S:L).Conclusion: Administration of Lactobacillus GG for 30 d had no effect on the intestinal integrity of 3-5-y-old Malawian children.