Voltage-gated K channels.
Voltage-gated K channels.
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DOI：
10.1126/stke.2003.188.re10
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发表时间：
2003-06-24
期刊：
影响因子：
--
通讯作者：
Armstrong, Clay M
中科院分区：
文献类型：
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作者：
Armstrong, Clay M
离子通道和它们赋予细胞的电特性与人类的每一个特征有关，这些特征使我们与田野中的石头区别开来。每一个感知、思想、运动和心跳都依赖于离子通道活动产生的电信号。通道结构和功能之间的关系的早期观点经历了重大修改后，克隆的各种离子通道和一个简单的细菌K通道，KcsA通道的结构的测定。本文综述了电压依赖性钾通道的结构和功能之间的关系，涵盖了通道选择性，传导和门控的分子基础。讨论了细菌中离子通道的进化，以及KcsA通道的通道选择性和传导的基础。更复杂的通道已经进化出分子“看门人”，允许它们通过打开、关闭和失活来对适当的刺激做出反应。
Ion channels and the electrical properties they confer on cells are involved in every human characteristic that distinguishes us from the stones in a field. Every perception, thought, movement, and heartbeat depends on electrical signals generated by the activity of ion channels. Early views of the relationship between channel structure and function have undergone substantial modification following the cloning of various ion channels and the determination of the structure of a simple bacterial K channel, the KcsA channel. This review focuses on the relationship between the structure and function of voltage-dependent K channels, covering the molecular bases of channel selectivity, conduction, and gating. The evolution of ion channels in bacteria is discussed, as well as the basis of channel selectivity and conduction in the KcsA channel. More complex channels have evolved molecular "gatekeepers," allowing them to respond to appropriate stimuli by opening, closing, and inactivating.