Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives
Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives
复制标题
DOI：
10.1016/j.bmc.2011.08.029
复制
发表时间：
2011-10-01
影响因子：
3.5
通讯作者：
Groutas, William C.
中科院分区：
文献类型：
--
作者：
Dou, Dengfeng;Alex, Deepu;Groutas, William C.
本文报道了一系列以1，2-苯并异噻唑-3（2 H）-酮为骨架的广谱抗真菌药物。初步的结构-活性关系研究已经确定了杂环、甲基和苯环的存在对于最佳抗真菌活性表现的重要性。(C)2011爱思唯尔有限公司保留所有权利。
A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity. (C) 2011 Elsevier Ltd. All rights reserved.