Quadrupole detection FT-ICR mass spectrometry offers deep profiling of residue oil: A systematic comparison of 2ω 7 Tesla versus 15 Tesla instruments
Quadrupole detection FT-ICR mass spectrometry offers deep profiling of residue oil: A systematic comparison of 2ω 7 Tesla versus 15 Tesla instruments
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DOI：
10.1002/ansa.202000123
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发表时间：
2021-06-01
期刊：
影响因子：
--
通讯作者：
Volmer, Dietrich A.
中科院分区：
文献类型：
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作者：
Ge, Jinfeng;Ma, Chao;Volmer, Dietrich A.
质量分辨能力是傅里叶变换离子回旋共振质谱（FT-ICR MS）的关键特征之一，它使复杂混合物的分子表征成为可能。四极杆（2 Ω）检测在FT-ICR MS性能方面向前迈出了重要的一步，因为它在给定的信号采集时间内将分辨率提高了一倍。然而，这种2 Ω检测技术是否真正取代了更高的磁场仍然是未知的。在这项研究中，使用2 Ω 7特斯拉FT-ICR和15特斯拉FT-ICR仪器表征渣油样品，并系统地比较分析品质因数。结果表明，2 Ω 7 T FT-ICR MS在复杂油样的深度剖析中提供了相当的性能，具有更好的信号强度和吸收模式处理的再现性。15 T FT-ICR MS提供了更精确的测量，更好地估计了样品的元素组成。据我们所知，这是第一项发表的研究，该研究彻底比较了低磁场仪器与高磁场FT-ICR-MS上2 Ω检测的性能。
Mass resolving power is one of the key features of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), which enables the molecular characterization of complex mixtures. Quadrupole (2 omega) detection provides a significant step forward in FT-ICR MS performance, as it doubles the resolving power for a given signal acquisition time. Whether this 2 omega detection technique truly substitutes for a higher magnetic field remains unknown however. In this study, a residue oil sample was characterized using both a 2 omega 7 Tesla FT-ICR and a 15 Tesla FT-ICR instrument, and analytical figures of merit were systematically compared. It was shown that 2 omega 7T FT-ICR MS provided comparable performance in the deep profiling of the complex oil sample, with better signal intensities and reproducibilities for absorption-mode processing. The 15T FT-ICR MS gave more precise measurements with better estimates of the sample's elemental compositions. To the best of our knowledge, this is the first published study, which thoroughly compared the performance of 2 omega detection on a low magnetic field instrument with that of a high magnetic field FT-ICR-MS.