Migration versus mutation in the evolution of recombination under multilocus selection.
Migration versus mutation in the evolution of recombination under multilocus selection.
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多位点选择下重组进化中的迁移与突变。
DOI：
10.1017/s0016672398003243
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Feldman,MW
中科院分区：
文献类型：
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作者：
Pylkov,KV;Zhivotovsky,LA;Feldman,MW
我们使用修饰语理论比较突变选择和迁移选择平衡模型下的重组进化。受弱多位点选择影响的松散连锁基因座间的连锁反应受选择性中性修饰基因座的基因型控制。我们表明，一个新的修饰剂的成功取决于上位性的标志和数量，以及在连锁的修饰基因座的基因座选择。对于迁移和突变，重组增加需要负（协同）上位性。当上位性足够弱时，在突变-选择平衡下增加重组总是有利的，而在迁移-选择平衡下从不有利。当负上位性较强时，存在一个临界重组值。在这种情况下，如果一个增加重组的等位基因与主要基因座的重组率小于临界重组值，那么它就会在突变选择平衡下侵入群体，而在弱迁移的情况下，它必须高于这个值。这些结果对于单倍体和二倍体群体是相同的。
We use modifier theory to compare the evolution of recombination under mutation–selection and migration–selection balance models. Recombination between loosely linked loci subject to weak multilocus selection is controlled by the genotype at a selectively neutral modifier locus. We show that the success of a new modifier depends on the sign and amount of epistasis as well as on the linkage of the modifier locus to the loci under selection. With both migration and mutation, for recombination to increase requires negative (synergistic) epistasis. When epistasis is sufficiently weak, increased recombination is always favoured under mutation–selection balance and never under migration–selection balance. With stronger negative epistasis, there exists a critical recombination value. In this case, a recombination-increasing allele invades the population under mutation–selection balance if its recombination rate with the major loci is less than the critical recombination value, whereas with weak migration it must be above this value. These results are the same for haploid and diploid populations.