EXPERIMENTAL INDUCTION OF ATHERO-ARTERIOSCLEROSIS BY THE SYNERGY OF ALLERGIC INJURY TO ARTERIES AND LIPID-RICH DIET
EXPERIMENTAL INDUCTION OF ATHERO-ARTERIOSCLEROSIS BY THE SYNERGY OF ALLERGIC INJURY TO ARTERIES AND LIPID-RICH DIET
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动脉过敏性损伤和高脂饮食协同作用诱导动脉粥样硬化的实验
DOI：
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发表时间：
1966
影响因子：
15.3
通讯作者：
Wallace G. Campbell
中科院分区：
文献类型：
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作者：
C. Minick;George E. Murphy;Wallace G. Campbell
在接受0.5%（重量）胆固醇膳食补充剂和同时注射马血清的家兔中，（III组）在80天的时间内，冠状动脉病变发展，其在质量和分布上主要不同于仅接受胆固醇补充剂的兔（I组），其质量与仅接受马血清的兔（组II）不同，但分布相似。组Ⅰ家兔的大、中、小动脉均出现脂肪性病变，中动脉少见，大动脉未见，与人冠状动脉粥样硬化不相似;组Ⅱ家兔的大、中、小动脉均出现无脂肪性病变，其中部分与人冠状动脉粥样硬化相似，无脂肪性病变。第III组家兔的大、中、小动脉中发生的变化绝大多数为脂肪增生性病变。在第II组和第III组家兔心脏增厚的动脉内膜中的许多增殖细胞和一些富含脂质的“泡沫”中，观察到纵切面染色质呈毛虫样，横切面呈猫头鹰眼样的细胞核。III组兔心脏动脉内膜和中膜下细胞。已经观察到这样的核出现在心脏的一些反应性平滑肌细胞和正常的未成熟和反应性成熟横纹肌细胞中。这些观察结果表明，在实验诱导的和自然发生的冠状动脉粥样硬化中增厚的内膜中至少有许多细胞，包括“泡沫”细胞，是在对动脉损伤的增殖反应中进化的平滑肌细胞。第I组和第III组家兔的乳房出现脂肪变化，第III组明显更大。本研究结果支持动脉过敏性损伤和高脂饮食的协同作用可导致动脉粥样硬化的假设。
In rabbits that received a dietary supplement of cholesterol, 0.5% by weight, and concommittant injections of horse serum (group III) over a period of 80 days, coronary arterial lesions developed that in the main were different in quality and distribution from those in rabbits that received the cholesterol supplement alone (group I), and of different quality from but in distribution similar to those in rabbits that received horse serum alone (group II). Fatty lesions developed in small, rarely in medium, but never in large arteries of rabbits in group I, and these changes do not resemble coronary athero-arteriosclerosis in man. Proliferative lesions without fatty change developed in large, medium, and small arteries of rabbits in group II, and some of these closely resemble human coronary arteriosclerosis without fatty change. The changes that developed in large, medium, and small arteries of rabbits in group III were in very large majority fatty-proliferative lesions. Some of these closely resemble the changes that in some cases constitute coronary athero-arteriosclerosis in man. Nuclei with caterpillarlike chromatin pattern in longitudinal section and owl eye appearance in transverse section were observed to occur in many of the proliferating cells in thickened arterial intima in hearts of rabbits in groups II and III and in some of the lipid rich "foam" cells in arterial intima and subjacent media in hearts of rabbits in group III. Such nuclei have been observed to occur in some reacting smooth muscle cells and normal immature and reacting mature striated muscle cells of the heart. These observations indicate that at least many of the cells, including "foam" cells, in thickened intima in the experimentally induced and in naturally occurring coronary athero-arteriosclerosis are smooth muscle cells that evolved in proliferative reaction to arterial injury. Fatty change developed in aortas of the rabbits in groups I and III, and was significantly greater in group III. Results of this investigation support the hypothesis that the synergy of allergic injury to arteries and lipid-rich diet can lead to athero-arteriosclerosis.