Actinic Keratosis and Squamous Cell Carcinoma
Actinic Keratosis and Squamous Cell Carcinoma
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光化性角化病和鳞状细胞癌
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
M. Lalji
中科院分区：
文献类型：
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作者：
A. Lalji;N. Khiroya;M. Lalji
背景：光化性角化病或日光性角化病是一种常见的皮肤病变，由日光损伤引起，可发展为鳞状细胞癌。有人认为光化性角化病实际上是原位SCC。目的：本文献回顾旨在探讨光化性角化病与鳞状细胞癌之间的差异，以及光化性角化病是否应作为鳞状细胞癌进行治疗。方法：回顾性分析光化性角化病与鳞状细胞癌的区别。我们使用以下检索词对Pubmed、科克伦和Medline中2000年1月1日至2014年4月30日期间发表的文章进行了检索：光化性角化病、日光性角化病、皮肤癌、鳞状细胞癌、皮肤镜检查、日光暴露、紫外线辐射和发育不良。选择英文发表的研究纳入本综述，并从参考书目中识别出其他文章。结果：光化性角化病与鳞状细胞癌鉴别困难。可能需要一个包括早期原位SCC型AK1、早期原位SCC型AK2和原位SCC型光化性角化病的分类系统。结论：光化性角化病侵犯基底膜，可能发展为浸润性鳞状细胞癌。浅表光化性角化病与浅表鳞状细胞癌无法区分，因此可能无法识别或诊断不准确。
Background: Actinic keratosis or solar keratosis is a common skin lesion caused by sun damage that progresses to squamous cell carcinoma. It has been suggested that actinic keratosis is in fact SCC in situ. Objective: This literature review was conducted to investigate the differences between actinic keratosis and squamous cell carcinoma and whether actinic keratosis should in fact be managed as squamous cell carcinoma. Methods: A literature review was conducted to assess the differences between actinic keratosis and squamous cell carcinoma. We conducted searches of Pubmed, Cochrane and Medline for articles published between January 1, 2000 and April 30, 2014, using the following search terms: actinic keratosis, solar keratosis, skin cancer, squamous cell carcinoma, dermoscopy, sun exposure, ultra violet radiation, and dysplasia. Studies published in English were selected for inclusion in this review as were additional articles identified from bibliographies. Results: It is difficult to distinguish between both actinic keratosis and squamous cell carcinoma. Perhaps a classification system for actinic keratosis including early in situ SCC type AK1, early in situ SCC type AK2 and in situ SCC type actinic keratosis is needed. Conclusion: Actinic keratosis invades the basement membrane and as such may progress into invasive SCC. Superficially actinic keratoses are not distinguishable from a superficial SCC and as such may go unrecognized or inaccurately diagnosed.
皮肤病变从正常皮肤进展为鳞状细胞癌。
DOI：
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发表时间：
2009
期刊：
Analytical and quantitative cytology and histology
影响因子：
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作者：
Krouse,RobertS;Alberts,DavidS;Prasad,AnilR;Yozwiak,Michael;Bartels,HubertG;Liu,Yun;Bartels,PeterH
通讯作者：
Bartels,PeterH