Antagonism by methysergide of the effects of l-5-hydroxytryptophan and quipazine on schedule-controlled responding
Antagonism by methysergide of the effects of l-5-hydroxytryptophan and quipazine on schedule-controlled responding
复制标题
美西麦角对 L-5-羟色氨酸和奎帕嗪对日程控制反应的影响的拮抗作用
DOI：
10.1016/0028-3908(81)90054-x
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发表时间：
1981
影响因子：
4.7
通讯作者：
J. Leander
中科院分区：
文献类型：
--
作者：
J. Leander
测定了l-5-羟色氨酸和喹帕嗪单独和存在小剂量（0.3和1 mg/kg）的甲基塞虫胺在多次固定比例30反应、固定间隔5分钟的谷物呈现时间表下的剂量效应曲线。两种5 -羟色胺能激动剂在两种计划成分的反应中均产生剂量相关的降低。甲塞吉胺对两种血清素能激动剂产生2- 3倍的剂量效应曲线右移（拮抗）。结论是-5-羟色氨酸和喹帕嗪通过作用于甲基塞肽敏感的5-羟色胺能受体而降低反应率。
Dose-effect curves forl-5-hydroxytryptophan and quipazine were determined alone and in the presence of small doses (0.3 and 1 mg/kg) of methysergide in pigeons responding under a multiple fixed-ratio 30-response, fixed-interval 5-min schedule of grain presentation. Both serotonergic agonists produced dose-related decreases in responding in both schedule components. Methysergide produced a 2- to 3-fold shift of the dose-effect curve to the right (antagonism) for both serotonergic agonists. It was concluded thatl-5-hydroxytryptophan and quipazine decrease rates of responding by an action at a methysergide-sensitive serotonergic receptor.