Impact of the day of the week on the discontinuation of broad-spectrum antibiotic prescriptions; a multi-centered observational study.
Impact of the day of the week on the discontinuation of broad-spectrum antibiotic prescriptions; a multi-centered observational study.
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DOI：
10.1038/s41598-021-00206-9
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发表时间：
2021-10-21
影响因子：
4.6
通讯作者：
Otsuka F
中科院分区：
文献类型：
--
作者：
Honda H;Hagiya H;Higashionna T;Haruki Y;Haruki M;Kajita S;Mukuda K;Yokoyama Y;Nakano Y;Ogawa H;Morimoto Y;Hanayama Y;Kanda S;Kataoka H;Muguruma H;Otsuka F
为了鼓励和指导抗菌药物管理团队（AST）的活动，促进合理的抗生素使用，我们研究了一周中的一天对抗生素给药的开始和停止的影响。这是一项多中心观察性研究，于2019年4月1日至9月30日在日本8家医院进行，目标是接受广谱抗生素治疗的患者，如抗甲氧西林耐药金黄色葡萄球菌药物和抗假单胞菌药物。我们比较了每周每一天或假期后几天抗生素处方的开始和停止的每周数量。在工作日和假期后的第二天，抗生素的使用数量没有统计学差异。然而，周二以后的抗生素停药率明显高于周一，假期后第二天的抗生素停药率明显高于假期后第一天。无论抗生素类别、医院和住院病房以及AST活性如何，都观察到类似的趋势。这项研究表明，广谱抗生素往往在周末和假期继续使用，最有可能在周二或假期后的第二天停止使用。这可能是由于医学适应症以外的行为因素，需要在未来进一步的抗菌素管理工作。
To encourage and guide antimicrobial stewardship team (AST) activity and promote appropriate antibiotic use, we studied the impact of day of the week on the initiation and discontinuation of antibiotic administration. This was a multicenter observational study conducted at 8 Japanese hospitals from April 1 to September 30, 2019, targeting patients who underwent treatment with broad-spectrum antibiotics, such as anti-methicillin-resistant Staphylococcus aureus agents and anti-pseudomonal agents. We compared the weekly numbers of initiations and discontinuations of antibiotic prescription on each day of the week or on the days after a holiday. There was no statistical difference in the number of antibiotic initiations on both weekdays and the day after a holiday. However, antibiotic discontinuation was significantly higher from Tuesday onward than Monday and from the second day than the first day after a holiday. Similar trends were observed regardless of the categories of antibiotics, hospital and admission ward, and AST activity. This study suggests that broad-spectrum antibiotics tend to be continued during weekends and holidays and are most likely to be discontinued on Tuesday or the second day after a holiday. This was probably due to behavioral factors beyond medical indications, requiring further antimicrobial stewardship efforts in the future.
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对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
影响因子：
2.8
作者：
Tolvi, Morag;Mattila, Kimmo;Lehtonen, Lasse
通讯作者：
Lehtonen, Lasse
影响因子：
2.1
作者：
Huibers, Linda;Moth, Grete;Vedsted, Peter
通讯作者：
Vedsted, Peter
DOI：
10.1016/j.ogc.2015.05.002
发表时间：
2015-09-01
影响因子：
3.2
作者：
Messler, Jordan;Whitcomb, Winthrop F.
通讯作者：
Whitcomb, Winthrop F.
影响因子：
158.5
作者：
Kostis, William J.;Demissie, Kitaw;Moreyra, Abel E.
通讯作者：
Moreyra, Abel E.