Endothelium enhances tachyphylaxis to angiotensins II and III in rat aorta.
Endothelium enhances tachyphylaxis to angiotensins II and III in rat aorta.
复制标题
内皮增强大鼠主动脉对血管紧张素 II 和 III 的快速耐受。
DOI：
10.1016/0014-2999(87)90745-x
复制
发表时间：
1987
影响因子：
5
通讯作者：
Schoepp,DD
中科院分区：
文献类型：
--
作者：
Gruetter,CA;Ryan,ET;Schoepp,DD
在有和不有功能性内皮的大鼠主动脉环上，比较了血管紧张素诱导收缩的快速反应的发展。内皮功能正常的大鼠主动脉对血管紧张素Ⅱ或血管紧张素Ⅲ引起的收缩反应迅速发生明显的快速反应。血管内皮的破坏显著抑制了血管紧张素Ⅱ或血管紧张素Ⅲ引起的收缩反应的快速反应，但不能阻止血管紧张素Ⅱ或血管紧张素Ⅲ引起的收缩反应的快速反应。
Development of tachyphylaxis to angiotensin-induced contraction was compared in rings of rat aorta with and without functional endothelium. Rat aorta with functional endothelium rapidly developed marked tachyphylaxis to contraction induced by angiotensin II or angiotensin III. Destruction of endothelium significantly depressed, but did not prevent, development of tachyphylaxis to contractile responses induced by repeated exposure to angiotensin II or angiotensin III. The findings suggest that two mechanisms are involved in the development of tachyphylaxis to angiotensin in rat aorta, an endothelium-dependent mechanism and an endothelium-independent mechanism.