Association between vitamin D status and physical performance: The InCHIANTI study
Association between vitamin D status and physical performance: The InCHIANTI study
复制标题
DOI：
10.1093/gerona/62.4.440
复制
发表时间：
2007-04-01
影响因子：
5.1
通讯作者：
Kritchevskyl, Stephen B.
中科院分区：
文献类型：
--
作者：
Houston, Denise K.;Cesari, Matteo;Kritchevskyl, Stephen B.
背景维生素D的状态已被假设在肌肉骨骼功能中发挥作用。使用InChianti研究的数据，我们研究了维生素D状态和身体表现之间的关系。纳入了976名研究基线时年龄≥ 65岁的代表性样本。使用短期体能测试组合（SPPB）和握力评估体能。采用多元线性回归分析维生素D（血清25 OHD）、甲状旁腺激素（PTH）和体能之间的关系，调整社会人口学变量、行为特征、体重指数、季节、认知、健康状况、肌酐、血红蛋白和白蛋白。大约28.8%的女性和13.6%的男性的维生素D水平表明缺乏（血清25 OHD < 25.0 nmol/L），74.9%的女性和51.0%的男性的维生素D水平表明维生素D不足（血清25 OHD < 50.0 nmol/L）。维生素D水平与男性SPPB评分（β系数[标准误（SE）]：0.38 [0.18]，p = 0.04）以及男性（2.44 [0.84]，p = 0.004）和女性（1.33 [0.53]，p = 0.01）的握力显著相关。血清25 OHD < 25.0 nmol/L的男性和女性的SPPB评分显著低于血清25 OHD>= 25和>= 50 nmol/L的患者，而血清25 OHD < 50 nmol/L的患者的握力显著低于血清25 OHD>= 25和>= 50 nmol/L的患者（p <0.05）。PTH仅与握力显著相关（p = 0.01）。维生素D状况与身体表现不佳呈负相关。鉴于维生素D缺乏症在老年人群中的高患病率，需要进一步研究维生素D状况与身体功能之间的关系。
Background. Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance.Methods. A representative sample of 976 persons aged 65 years or older at study baseline were included. Physical performance was assessed using a short physical performance battery (SPPB) and handgrip strength. Multiple linear regression was used to examine the association between vitamin D (serum 25OHD), parathyroid hormone (PTH), and physical performance adjusting for sociodemographic variables, behavioral characteristics, body mass index, season, cognition, health conditions, creatinine, hemoglobin, and albumin.Results. Approximately 28.8% of women and 13.6% of men had vitamin D levels indicative of deficiency (serum 25OHD < 25.0 nmol/L) and 74.9% of women and 51.0% of men had vitamin D levels indicative of vitamin D insufficiency (serum 25OHD < 50.0 nmol/L). Vitamin D levels were significantly associated with SPPB score in men (beta coefficient [standard error (SE)]: 0.38 [0.18], p = .04) and handgrip strength in men (2.44 [0.84], p = .004) and women (1.33 [0.53], p = .01). Men and women with serum 25OHD < 25.0 nmol/L had significantly lower SPPB scores whereas those with serum 25OHD < 50 nmol/L had significantly lower handgrip strength than those with serum 25OHD >= 25 and >= 50 nmol/L, respectively (p < .05). PTH was significantly associated with handgrip strength only (p = .01).Conclusions. Vitamin D status was inversely associated with poor physical performance. Given the high prevalence of vitamin D deficiency in older populations, additional studies examining the association between vitamin D status and physical function are needed.