Platelet-rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans: A comparative controlled clinical study
Platelet-rich plasma combined with a porous hydroxyapatite graft for the treatment of intrabony periodontal defects in humans: A comparative controlled clinical study
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DOI：
10.1902/jop.2005.76.6.890
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发表时间：
2005-06-01
影响因子：
4.3
通讯作者：
Yoshie, H
中科院分区：
文献类型：
--
作者：
Okuda, K;Tai, H;Yoshie, H
背景：目前的临床对照研究的目的是比较富血小板血浆(PRP)和可生物降解陶瓷、多孔羟基磷灰石(HA)以及HA和生理盐水的混合物治疗人类骨内缺损的效果。方法：选择70例健康、不吸烟的慢性牙周炎患者的近端骨内骨缺损。35名受试者被随机分配到试验组(PRP和HA)或对照组(HA+生理盐水)。结果：与基线相比，12个月的治疗结果显示，尽管两种治疗方法均导致所有临床参数(牙龈指数、探诊出血、探诊深度、临床附着水平和骨内缺损填充；P<；0.001)发生显著变化，但试验组在探诊深度减少方面与对照组相比有统计学意义的变化：4.7±1.6 mm比3.7±2.0 mm(P<；0.0 5)；垂直相对附着增益：70.3%+/-23.4%对45.5%+/-29.4%(P<；0.001)。
Background: The aim of the present controlled clinical study was to compare platelet-rich plasma (PRP) combined with a biodegradable ceramic, porous hydroxyapatite (HA) with a mixture of HA and saline in the treatment of human intrabony defects.Methods: Seventy interproximal intrabony osseous defects in 70 healthy, non-smoking subjects diagnosed with chronic periodontitis were included in this study. Thirty-five subjects each were randomly assigned to either the test group (PRP and HA) or control group (HA with saline). Clinical and radiographic measurements were determined at baseline and the 12-month evaluation.Results: When compared to baseline, the 12-month results indicated that, while both treatment modalities resulted in significant changes in all clinical parameters (gingival index, bleeding on probing, probing depth, clinical attachment level, and intrabony defect fill; P < 0.001), the test group exhibited statistically significant changes compared to the control sites in probing depth reduction: 4.7 +/- 1.6 mm versus 3.7 +/- 2.0 mm (P < 0.05); clinical attachment gain: 3.4 +/- 1.7 mm versus 2.0 +/- 1.2 mm (P < 0.001); and vertical relative attachment gain: 70.3% +/- 23.4% versus 45.5% +/- 29.4% (P < 0.001).Conclusion: Treatment with a combination of PRP and HA compared to HA with saline led to a significantly more favorable clinical improvement in intrabony periodontal defects.