COMPARATIVE EFFICACY AND SAFETY OF THE NONSTEROIDAL ANTI‐INFLAMMATORY DRUGS NIMESULIDE AND DICLOFENAC IN PATIENTS WITH ACUTE SUBDELTOID BURSITIS AND BICIPITAL TENDINITIS
COMPARATIVE EFFICACY AND SAFETY OF THE NONSTEROIDAL ANTI‐INFLAMMATORY DRUGS NIMESULIDE AND DICLOFENAC IN PATIENTS WITH ACUTE SUBDELTOID BURSITIS AND BICIPITAL TENDINITIS
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非甾体类抗炎药尼美舒利和双氯芬酸对急性三角肌下滑囊炎和二头肌腱炎患者的疗效和安全性比较
DOI：
10.1111/j.1742-1241.1998.tb11598.x
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发表时间：
1998
影响因子：
2.6
通讯作者：
A. Macciocchi
中科院分区：
文献类型：
--
作者：
W. Wober;VW Rahlfs;N. Büchl;A. Grässle;A. Macciocchi
比较了尼美舒利（一种非甾体抗炎药（NSAID））100 mg每日两次与双氯芬酸75 mg每日两次的疗效和耐受性。短期治疗成人急性肩关节（急性三角肌下滑囊炎和股骨头肌腱炎）。在这项为期两周的双盲（双模拟）、随机、平行组研究中，纳入了122例患者。Mann-Whitney统计显示两种治疗的治疗等效性，尼美舒利略优。尼美舒利的耐受性，由研究者和患者判断和统计学分析，上级双氯芬酸。因此，试验药物的获益-风险关系优于参比药物。
The efficacy and tolerability of nimesulide, a non‐steroidal anti‐inflammatory drug (NSAID) 100 mg twice daily were compared with diclofenac 75 mg b.i.d. in short term treatment of acute shoulder (acute subdeltoid bursitis and bicipital tendinitis) in adult patients. In this double‐blind (double‐dummy), randomised, parallel group study over two weeks, 122 patients were included. The Mann‐Whitney statistics revealed therapeutic equivalence of both treatments with a slight superiority for nimesulide. The tolerability of nimesulide, judged by investigators and patients and analysed statistically, was superior to that of diclofenac. Thus, the benefit‐risk relationship was better for the test drug than for the reference drug.