Macrophage plasminogen activator: induction by products of activated lymphoid cells
Macrophage plasminogen activator: induction by products of activated lymphoid cells
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巨噬细胞纤溶酶原激活剂：活化淋巴细胞的诱导产物
DOI：
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发表时间：
1977
影响因子：
15.3
通讯作者：
Reich
中科院分区：
文献类型：
--
作者：
Jean;Reich
从未经处理的小鼠腹腔中获得的巨噬细胞通常不合成纤溶酶原激活物。然而，当这些巨噬细胞在来自Con A刺激的脾细胞的条件培养基存在下培养时，发生酶合成和分泌的诱导。来自内毒素或巯基乙酸盐培养基注射的小鼠的巨噬细胞的纤溶酶原激活物的产生，其自发地分泌大量的酶，在这种条件培养基的存在下也显著增加。这些结果表明，巨噬细胞纤溶酶原活化生产可能是由淋巴细胞调节的一部分。他们提供了进一步的证据，巨噬细胞纤溶酶原激活剂与细胞迁移和炎症的联系，也支持这样的观点，即在巨噬细胞，在某些其他类型的细胞，这种酶的合成和分泌激素控制。
Macrophages obtained from the peritoneal cavity of untreated mice do not ordinarily synthesize plasminogen activator. However, induction of enzyme synthesis and secretion occurs when such macrophages are cultured in presence of conditioned medium from Con A-stimulated spleen cells. Plasminogen activator production by macrophages from endotoxin or thioglycollate medium-injected mice, which spontaneously secrete substantial amounts of the enzyme, is also markedly increased in presence of such conditioned medium. These results suggest that macrophage plasminogen activatory production may be regulated in part by lymphocytes. They provide further evidence to link macrophage plasminogen activator with cell migration and inflammation, and also support the view that in macrophages, as in certain other cell types, synthesis and secretion of this enzyme are under hormonal control.