Intramyocellular lipid droplets and insulin sensitivity, the human perspective
Intramyocellular lipid droplets and insulin sensitivity, the human perspective
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DOI：
10.1016/j.bbalip.2017.07.010
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发表时间：
2017-10-01
影响因子：
4.8
通讯作者：
Hesselink, Matthijs K. C.
中科院分区：
文献类型：
--
作者：
Gemmink, Anne;Goodpaster, Bret H.;Hesselink, Matthijs K. C.
骨骼肌可以将多余的脂肪储存为亚细胞脂滴（LDs）。虽然最初被认为是无趣的静态球的三酰甘油，现在很清楚，肌细胞LD在肌细胞（病理）生理学中发挥积极作用。在这篇综述中，我们的目的是讨论的LD在肌细胞胰岛素敏感性的作用，并确定出现影响这种关系的参数。此外，我们讨论了新的工具，允许详细检查这些参数的应用。这篇文章是由Rosalind科尔曼和Matthijs Hesselink编辑的题为：脂滴生物学最新进展的特刊的一部分。
Skeletal muscle can store excess fat as subcellular lipid droplets (LDs). While originally viewed as uninteresting static balls of triacylglycerol, it is now clear that myocellular LDs play an active role in myocellular (patho) physiology. In this review we aim to discuss the role of LDs in muscle cell insulin sensitivity and identify parameters which appear to affect this relationship. Moreover, we discuss the application of novel tools permitting detailed examination of these parameters. This article is part of a Special Issue entitled: Recent Advances in Lipid Droplet Biology edited by Rosalind Coleman and Matthijs Hesselink.