Pd-Catalyzed Acetoxylation of γ-C(sp3)–H Bonds of Amines Directed by a Removable Bts-Protecting Group
Pd-Catalyzed Acetoxylation of γ-C(sp3)–H Bonds of Amines Directed by a Removable Bts-Protecting Group
复制标题
由可去除的 Bts 保护基团引导的 Pd 催化胺 γ-C(sp3)–H 键的乙酰氧基化
DOI：
10.1021/acs.joc.7b02995
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Lijiang Xuan
中科院分区：
文献类型：
--
作者：
Yong Zhong;Weibin Song;Yefu Zhu;Bole Wei;Lijiang Xuan
报道了以廉价的PhI（OAc）2为氧化剂，Pd催化的Bts保护的胺的γ-C（sp3）-H键的乙酰氧基化反应。Bts保护基在温和条件下容易引入和除去。该方案为γ-羟基胺衍生物的构建提供了一个重要的策略。
Pd-catalyzed acetoxylation of γ-C(sp3)–H bonds directed by Bts-protected amines using inexpensive PhI(OAc)2as oxidant is reported. The Bts-protecting group is easily introduced and removed under mild conditions. This protocol provides an important strategy for the construction of γ-hydroxyl amine derivatives.