Jet nebulization of prostaglandin E1 during neonatal mechanical ventilation: stability, emitted dose and aerosol particle size.
Jet nebulization of prostaglandin E1 during neonatal mechanical ventilation: stability, emitted dose and aerosol particle size.
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DOI：
10.1016/j.phrs.2007.09.017
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发表时间：
2007-12
影响因子：
9.3
通讯作者：
B. Sood;J. Peterson;M. Malian;R. Galli;Maria Geisor-Walter;J. Mckinnon;J. Sharp;K. Maddipati
中科院分区：
文献类型：
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作者：
B. Sood;J. Peterson;M. Malian;R. Galli;Maria Geisor-Walter;J. Mckinnon;J. Sharp;K. Maddipati
我们以前曾报道过雾化吸入PGE 1治疗新生儿低氧性呼吸衰竭的安全性。目的：研究PGE 1气雾剂的理化性质、稳定性、释放剂量和空气动力学粒径分布（APSD）。化学稳定性和发射剂量进行了评价，在新生儿常规（CMV）或高频（HFV）呼吸机回路喷射雾化期间，通过高效液相色谱-质谱法。在CMV过程中，用6级级联撞击器评价了PGE 1气雾剂的APSD。TSPGE 1在生理盐水中的溶液具有低粘度（0.9818cP）和低表面张力（60.8mN/m），适合于气雾化。在来自气雾剂冷凝物、输注超过24小时的PGE 1溶液或喷雾器中的残留溶液的样品中观察到很少或没有PGE 1降解。喷射雾化后的PGE 1释放量在CMV期间为32-40%，在HFV期间为0.1%。PGE 1气溶胶的质量中值空气动力学直径为1.4μm，几何S.D.结论在新生儿CMV或HFV期间雾化吸入PGE 1是有效的，并且在不改变化学结构的情况下导致快速雾化。基于PGE 1溶液的物理化学性质和PGE 1气溶胶的APSD，可以预测雾化PGE 1的主要肺泡沉积。
BACKGROUNDWe have previously reported the safety of aerosolized PGE1in neonatal hypoxemic respiratory failure. The aim of this study is to characterize the physicochemical properties of PGE1solution, stability, emitted dose and the aerodynamic particle size distribution (APSD) of PGE1aerosol in a neonatal ventilator circuit.METHODSPGE1was diluted in normal saline and physicochemical properties of the solution characterized. Chemical stability and emitted dose were evaluated during jet nebulization in a neonatal conventional (CMV) or high frequency (HFV) ventilator circuit by a high performance liquid chromatography–mass spectrometry method. The APSD of the PGE1aerosol was evaluated with a 6-stage cascade impactor during CMV.RESULTSPGE1solution in normal saline had a low viscosity (0.9818cP) and surface tension (60.8mN/m) making it suitable for aerosolization. Little or no degradation of PGE1was observed in samples from aerosol condensates, the PGE1solution infused over 24h, or the residual solution in the nebulizer. The emitted dose of PGE1following jet nebulization was 32–40% during CMV and 0.1% during HFV. The PGE1aerosol had a mass median aerodynamic diameter of 1.4μm and geometric S.D. of 2.9 with 90% of particles being <4.0μm in size.CONCLUSIONNebulization of PGE1during neonatal CMV or HFV is efficient and results in rapid nebulization without altering the chemical structure. On the basis of the physicochemical properties of PGE1solution and the APSD of the PGE1aerosol, one can predict predominantly alveolar deposition of aerosolized PGE1.