Adrenergic and cholinergic nerves mediate fluid secretion from tracheal glands of ferrets.
Adrenergic and cholinergic nerves mediate fluid secretion from tracheal glands of ferrets.
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肾上腺素能神经和胆碱能神经介导雪貂气管腺的液体分泌。
DOI：
10.1152/jappl.1980.49.6.1027
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Nadel,JA
中科院分区：
文献类型：
--
作者：
Borson,DB;Chin,RA;Davis,B;Nadel,JA
我们的目的是确定肾上腺素能神经和胆碱能神经是否介导气管粘膜下腺的液体分泌，如果是，通过哪些受体。为此，我们在体外研究了特定神经阻滞剂和自主神经拮抗剂存在和不存在的情况下，气管段对电和药理学刺激的分泌反应。刺激产生了小海拔，或“小丘”，我们通过测量它们的直径来估计它们的大小。我们发现电刺激、乙酰胆碱和苯肾上腺素都能引起分泌，但特布他林没有。河豚毒素对电刺激的分泌反应有抑制作用，但对乙酰胆碱和苯肾上腺素的分泌反应没有抑制作用。单独使用阿托品和酚妥拉明都不能阻止对电刺激的反应，但两种药物联合使用可以，心得安也不能抑制对电刺激反应的肾上腺素能成分。阿托品阻断对乙酰胆碱的反应，酚妥拉明阻断对苯肾上腺素的反应。我们认为肾上腺素能神经和胆碱能神经分别通过肾上腺素能受体和毒蕈碱受体调节雪貂气管腺的分泌。
Our aim was to determine whether adrenergic as well as cholinergic nerves mediate secretion of fluids from tracheal submucosal glands and, if so, via which receptors. To do this, we studied the secretory responses of tracheal segments to electrical and pharmacologic stimulation in vitro in the presence and absence of a specific nerve blocker and autonomic antagonists. Stimulation caused small elevations, or "hillocks," the size of which we estimated by measuring their diameters. We found that electrical stimulation, acetylcholine, and phenylephrine each caused secretion but that terbutaline did not. Tetrodotoxin prevented the secretory response to electrical stimulation but did not prevent the responses to acetylcholine or phenylephrine. Neither atropine nor phentolamine alone prevented the response to electrical stimulation, but both drugs together did, and propranolol did not inhibit the adrenergic component of the response to electrical stimulation. Atropine blocked the response to acetylcholine, and phentolamine blocked the response to phenylephrine. We conclude that adrenergic and cholinergic nerves mediate secretion from the tracheal glands of ferrets via alpha-adrenergic and muscarinic receptors, respectively.