Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans.
Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans.
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DOI：
10.1021/jf061889r
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发表时间：
2006-08
影响因子：
6.1
通讯作者：
J. Suomela;M. Ahotupa;Baoru Yang;T. Vasankari;H. Kallio
中科院分区：
文献类型：
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作者：
J. Suomela;M. Ahotupa;Baoru Yang;T. Vasankari;H. Kallio
沙棘 (Hippophaë rhamnoides L.) 是黄酮醇的丰富来源，尤其是异鼠李素。大多数前瞻性队列研究表明类黄酮摄入量与冠心病之间存在一定程度的负相关。动物和人体研究表明，沙棘黄酮类化合物可以清除自由基，降低血液粘度，增强心脏功能。研究了沙棘黄酮醇苷元对心血管疾病危险因素及其吸收的影响。与燕麦粥一起摄入的黄酮醇对氧化低密度脂蛋白、C反应蛋白和同型半胱氨酸的水平、血浆抗氧化潜力或对氧磷酶活性没有显着影响。燕麦粥中两种剂量的黄酮醇被迅速吸收，并且在燕麦粥中添加相对少量的沙棘油似乎增加了较高剂量消耗的沙棘黄酮醇的生物利用度。
Sea buckthorn (Hippophaë rhamnoides L.) is a rich source of flavonols, especially isorhamnetin. Most prospective cohort studies have indicated some degree of inverse association between flavonoid intake and coronary heart disease. Animal and human studies suggest that sea buckthorn flavonoids may scavenge free radicals, lower blood viscosity, and enhance cardiac function. The effects of flavonol aglycones derived from sea buckthorn on the risk factors of cardiovascular disease as well as their absorption were studied in humans. The flavonols, ingested with oatmeal porridge, did not have a significant effect on the levels of oxidized low-density lipoprotein, C-reactive protein, and homocysteine, on the plasma antioxidant potential, or on the paraoxonase activity. Flavonols at two dosages in oatmeal porridge were rapidly absorbed, and a relatively small amount of sea buckthorn oil added to the porridge seemed to have increased the bioavailability of sea buckthorn flavonols consumed at the higher dose.