Identification of a respiratory related area in the rat insular cortex
Identification of a respiratory related area in the rat insular cortex
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DOI：
10.1139/cjpp-78-7-582
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发表时间：
2000-07-01
影响因子：
2.1
通讯作者：
Bagaev, VA
中科院分区：
文献类型：
--
作者：
Aleksandrov, VG;Aleksandrova, NP;Bagaev, VA
这项研究的目的是绘制大鼠岛叶皮质内产生呼吸反应的区域，并将这些区域与胃肠道控制区进行比较。系统地微刺激岛叶皮质，并确定反应部位的组织学位置。吸气流量增加和呼吸周期缩短被认为是呼吸兴奋性反应。这些反应定位于颗粒障碍和无颗粒的岛叶皮质，位于前连合的尾侧水平。更多的是，呼吸抑制反应被激发：这些反应表现为吸气气流减少，而呼吸周期持续时间没有明显改变。呼吸抑制反应通常伴随着胃动力的改变。这些结果表明，大鼠岛叶皮质的呼吸区由两个不同的区域组成，这两个区域重叠着一个调节胃肠活动的区域。
The aim of this study was to map areas within the rat insular cortex from which respiratory responses originate and compare those sites with gastrointestinal control regions. The insular cortex was systematically microstimulated and histological location of responsive sites determined. Increased inspiratory airflow and decreased respiratory cycle duration were considered to be respiratory excitatory responses. The responses were localized in dysgranular and agranular insular cortex at levels caudal to the joining of the anterior commissure. More rostrally, respiratory inhibitory responses were elicited: these were manifested as a decrease in inspiratory airflow without a significant alteration in respiratory cycle duration. Respiratory inhibitory responses were usually accompanied by changes in gastric motility. These results suggest that the respiratory area in the rat insular cortex consist of two distinct zones which overlap a region modulating the gastrointestinal activity.