STUDIES WITH TULAREMIA VACCINES IN VOLUNTEERS .6. BRUCELLA AGGLUTININS IN VACCINATED AND NONVACCINATED VOLUNTEERS CHALLENGED WITH PASTEURELLA TULARENSIS
STUDIES WITH TULAREMIA VACCINES IN VOLUNTEERS .6. BRUCELLA AGGLUTININS IN VACCINATED AND NONVACCINATED VOLUNTEERS CHALLENGED WITH PASTEURELLA TULARENSIS
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DOI：
10.1097/00000441-196108000-00004
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发表时间：
1961-01-01
影响因子：
3.1
通讯作者：
CARLISLE, HN
中科院分区：
文献类型：
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作者：
SASLAW, S;CARLISLE, HN
用酚化土拉菌病菌苗免疫的43名志愿者中有16名血清中有布鲁氏菌凝集素，用土拉菌病减毒活菌苗免疫的28名志愿者中也有5名血清中有布鲁氏菌凝集素。15只兔用灭活土拉菌免疫后，均产生抗Br的凝集素。未接种疫苗的志愿者感染了毒性土拉菌病细菌，也表现出抗Br的凝集素。12例皮内给药后和14例呼吸道给药后，血清中分别有3例和3例出现流产。在30名接种疫苗的志愿者中，只有一名志愿者通过皮内或呼吸道途径感染了烈性土拉菌，结果显示布鲁氏菌凝集素升高。在所有情况下，抗土拉菌的滴度都高于抗布鲁氏菌的滴度。这些研究强调了这种交叉反应，并证实了其他人在自然获得性土拉菌病病例中的观察结果[thisBulletin，1927，v. 2，230; 1952，v. 27，1025];它们是在实验性土拉菌病临床方面所做研究的延续[同上，1961年，第36，1143和以上。R.洛弗尔
The sera of human volunteers immunized with a phenolized tularaemia vaccine were tested for agglu-tinins againstBrucella abortus, and in 16 of 43, significant titres were obtained.Brucellaagglutinins were also observed in the sera of 5 of 28 volunteers immunized with a viable attenuated tularaemia vaccine. All of 15 rabbits immunized with killed tularaemia bacteria possessed agglutinins againstBr. abortusin their sera.Non-vaccinated volunteers who had been infected with virulent tularaemia bacteria also exhibited agglutinins againstBr. abortusin their sera, 3 of 12 after intracutaneous and 3 of 14 after administration by the respiratory route. One alone of 30 vaccinated volunteers, who had been infected with virulent tularaemia bacteria by intracutaneous or respiratory routes showed a rise inBrucellaagglutinins.In all cases, the titres against the tularaemia bacteria were higher than those againstBrucella. These studies emphasize this cross-reaction and confirm the observations of others who have noted it in cases of naturally acquired tularaemia [thisBulletin, 1927, v. 2, 230; 1952, v. 27, 1025]; they are a continuation of those made in the clinical aspects of experimental tularaemia [ibid., 1961, v. 36, 1143, and above.]R. Lovell.