Clinical evaluation of allogeneic cultured dermal substitutes for intractable skin ulcers after tumor resection.
Clinical evaluation of allogeneic cultured dermal substitutes for intractable skin ulcers after tumor resection.
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同种异体培养真皮替代品治疗肿瘤切除后顽固性皮肤溃疡的临床评价。
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发表时间：
2004
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通讯作者：
M. Furue
中科院分区：
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作者：
Y. Moroi;Shohei Fujita;S. Fukagawa;T. Mashino;Takako Goto;Teiichi Masuda;K. Urabe;K. Kubo;Hiromichi Matsui;S. Kagawa;Y. Kuroyanagi;M. Furue
在日本厚生劳动省千禧年计划的支持下，北里大学人工皮肤研发中心新开发的同种异体培养真皮替代物(CDS)在日本各地的医学中心进行了临床研究。同种异体CDS是通过将成纤维细胞培养在双层的透明质酸和胶原海绵基质上而制备的。本文报道了12例皮肤肿瘤切除术后全层皮肤缺损患者应用同种异体CDS的临床结果。在10名患者中，有9名患者立即形成了健康的肉芽组织，这使得我们能够在早期进行中厚皮片移植。在两个病例中，使用同种异体CDS覆盖用于治疗大型溃疡的扩张网状皮肤移植物，并观察到快速上皮化。CDS治疗后无一例发生局部感染或局部肿瘤复发。海绵基质本身以及同种异体CDS释放的血管内皮生长因子(VEGF)似乎对顽固性皮肤溃疡的治疗有利。同种异体CDS是一种很好的生物敷料，可以极大地改变顽固性皮肤溃疡的治疗方法。
Clinical research on allogeneic cultured dermal substitute (CDS), which was newly developed at the R&D Center for Artificial Skin of Kitasato University, has been carried out in medical centers across Japan with the support of the Millennium Project of the Ministry of Health, Labor and Welfare of Japan. Allogeneic CDS was prepared by cultivation of fibroblasts on a two-layered spongy matrix of hyaluronic acid and atelo-collagen. This paper reports the clinical results of application of allogeneic CDS in 12 patients with full-thickness skin defects after surgical resection of skin tumors. In 9 of 10 patients, healthy granulation tissue developed immediately, allowing us to perform split-thickness skin grafts at an early stage. In two cases, allogeneic CDS was used to cover an expanded mesh skin graft that had been applied to treat a large ulcer, and rapid epithelization was observed. No patient developed local infection nor local tumor recurrence after treatment with CDS. The spongy matrix itself as well as the vascular endothelial growth factor (VEGF) released by the allogeneic CDS seemed to be beneficial for the treatment of intractable skin ulcers. Allogeneic CDS functions as an excellent biological dressing, and could dramatically change the treatment of intractable skin ulcers.