Seroprevalence and distribution of arboviral infections among rural Kenyan adults: A cross-sectional study
Seroprevalence and distribution of arboviral infections among rural Kenyan adults: A cross-sectional study
复制标题
DOI：
10.1186/1743-422x-8-371
复制
发表时间：
2011-07-27
期刊：
影响因子：
4.8
通讯作者：
Adungo, Nicholas
中科院分区：
文献类型：
--
作者：
Mease, Luke E.;Coldren, Rodney L.;Adungo, Nicholas
背景：节肢动物传播的病毒（虫媒病毒）在撒哈拉以南非洲地区引起广泛发病，但很少有研究记录这些病原体的负担和分布。方法：采用基于人群的横断面研究设计，我们进行了详细的调查问卷，并使用 ELISA 检测了来自三个地区的 1,141 名健康肯尼亚成年人的血液中是否存在针对以下病毒的抗病毒免疫球蛋白 G (IgG) 抗体：登革热 (DENV)、西尼罗河病毒（WNV）、黄热病病毒（YFV）、基孔肯雅病毒（CHIKV）和裂谷热病毒（RVFV）。结果：其中DENV阳性14.4%，WNV阳性9.5%，YFV阳性9.2%，CHIKV阳性34.0%，RVFV阳性0.7%。总共，46.6% 的人至少具有其中一种虫媒病毒的抗体。结论：对于所有虫媒病毒，居住地区与血清阳性密切相关。 YFV、DENV 和 WNV 的血清阳性率随着年龄的增长而增加，而年龄和 CHIKV 血清阳性率之间没有相关性，这表明 CHIKV 血清阳性率大部分是由于散发性流行造成的。矛盾的是，识字率与 CHIKV 和 DENV 血清阳性率增加有关。
Background: Arthorpod-borne viruses (arboviruses) cause wide-spread morbidity in sub-Saharan Africa, but little research has documented the burden and distribution of these pathogens.Methods: Using a population-based, cross-sectional study design, we administered a detailed questionnaire and used ELISA to test the blood of 1,141 healthy Kenyan adults from three districts for the presence of anti-viral Immunoglobulin G (IgG) antibodies to the following viruses: dengue (DENV), West Nile (WNV), yellow fever (YFV), Chikungunya (CHIKV), and Rift Valley fever (RVFV).Results: Of these, 14.4% were positive for DENV, 9.5% were WNV positive, 9.2% were YFV positive, 34.0% were positive for CHIKV and 0.7% were RVFV positive. In total, 46.6% had antibodies to at least one of these arboviruses.Conclusions: For all arboviruses, district of residence was strongly associated with seropositivity. Seroprevalence to YFV, DENV and WNV increased with age, while there was no correlation between age and seropositivity for CHIKV, suggesting that much of the seropositivity to CHIKV is due to sporadic epidemics. Paradoxically, literacy was associated with increased seropositivity of CHIKV and DENV.