Characterizing decision-making and reward processing in bipolar disorder: A cluster analysis
Characterizing decision-making and reward processing in bipolar disorder: A cluster analysis
复制标题
DOI：
10.1016/j.euroneuro.2018.04.001
复制
发表时间：
2018-07-01
影响因子：
5.6
通讯作者：
Benabarre, A.
中科院分区：
文献类型：
--
作者：
Jimenez, E.;Sole, B.;Benabarre, A.
双相情感障碍患者（BP）的情绪决策和奖励处理异常的存在已被充分证实。这些干扰并不局限于急性期，甚至在缓解期也很常见。近年来，这种精神病学人群中存在的离散认知概况已经被复制。然而，对情绪决策和奖励加工领域的研究却很少。因此，我们的目的是探讨在上述认知维度中BR的不同概况的存在。样本包括126个健康BR，收集了主要的社会人口学、临床、功能和神经认知变量。基于爱荷华赌博任务的表现，采用层次聚类技术来识别离散的神经认知特征。之后，使用方差分析或卡方检验对所得聚类进行比较。提供了存在三种不同侧面的证据。聚类1的主要特征是决策能力差。集群2对惩罚的敏感度最低。最后，聚类3表现出最佳决策能力和最高惩罚敏感性。三组比较表明，第2组是功能受损最严重的组。在注意力、执行功能领域和社会认知方面的最差结果也在同一组中观察到。总之，与在“冷认知”领域观察到的结果相似，我们的研究结果表明，存在三种有关情绪决策和奖励处理的离散认知概况。在所有研究的指标中，低惩罚敏感性与双相情感障碍较差的认知和功能结果有潜在的相关性。(C) 2018 Elsevier B.V.和ECNP。版权所有。
The presence of abnormalities in emotional decision-making and reward processing among bipolar patients (BP) has been well rehearsed. These disturbances are not limited to acute phases and are common even during remission. In recent years, the existence of discrete cognitive profiles in this psychiatric population has been replicated. However, emotional decision making and reward processing domains have barely been studied. Therefore, our aim was to explore the existence of different profiles on the aforementioned cognitive dimensions in BR The sample consisted of 126 euthymic BR Main sociodemographic, clinical, functioning, and neurocognitive variables were gathered. A hierarchical-clustering technique was used to identify discrete neurocognitive profiles based on the performance in the Iowa Gambling Task. Afterward, the resulting clusters were compared using ANOVA or Chi-squared Test, as appropriate. Evidence for the existence of three different profiles was provided. Cluster 1 was mainly characterized by poor decision ability. Cluster 2 presented the lowest sensitivity to punishment. Finally, cluster 3 presented the best decision-making ability and the highest levels of punishment sensitivity. Comparison between the three clusters indicated that cluster 2 was the most functionally impaired group. The poorest outcomes in attention, executive function domains, and social cognition were also observed within the same group. In conclusion, similarly to that observed in "cold cognitive" domains, our results suggest the existence of three discrete cognitive profiles concerning emotional decision making and reward processing. Amongst all the indexes explored, low punishment sensitivity emerge as a potential correlate of poorer cognitive and functional outcomes in bipolar disorder. (C) 2018 Elsevier B.V. and ECNP. All rights reserved.