False-negative food challenges
False-negative food challenges
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假阴性食物挑战
DOI：
10.1016/s0140-6736(02)08006-6
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
D. Freed
中科院分区：
文献类型：
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作者：
D. Freed
虽然这种综合征从未被认为是影响NASH进展的因素，主要见于肥胖患者，但值得注意的是，已报告了阻塞性睡眠呼吸暂停引起的缺血性肝炎，5并且日间气体交换受损导致呼吸功能不全的频率高于阻塞性睡眠呼吸暂停综合征。4因此，我们展示了1例NASH合并Pickwickian综合征的病例，并提示肥胖-肺换气不足综合征中的低氧血症可能是这种疾病中肝纤维化进展的一个夸大因素，因为肝细胞对缺氧非常敏感，它通过加速肝细胞的破坏来实现。一名63岁的男性，体重指数为38.0 kg/m2，主诉白天嗜睡。他的昼夜部分
Although this syndrome has never been recognised as a factor affecting the progression of NASH, seen mostly in obese patients, it is noteworthy that ischaemic hepatitis due to obstructive sleep apnoea has been reported, 5 and that daytime impaired gas exchange causes respiratory insufficiency more frequently than the obstructive sleep apnoea syndrome. 4 Therefore, we show a case of NASH with Pickwickian syndrome, and suggest that hypoxaemia in the obesity-hypoventilation syndrome could be an exaggerating factor in the progression of liver fibrosis in this disorder through accelerating hepatocyte destruction since hepatocytes are very sensitive to hypoxia. A man aged 63 years with a bodymass index of 38· 0 kg/m2 complained of daytime somnolence. His diurnal partial