Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?
Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient?
复制标题
癌症患者中的人类抗独特型抗体：免疫反应的调节对患者有益吗？
DOI：
10.1073/pnas.81.1.216
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发表时间：
1984
影响因子：
11.1
通讯作者：
Sears,HF
中科院分区：
文献类型：
--
作者：
Koprowski,H;Herlyn,D;Lubeck,M;DeFreitas,E;Sears,HF
用小鼠单克隆抗体接种人类受试者导致产生与单克隆抗体结合位点反应的抗独特型抗体。这种反应是半抗原抑制的，表明抗原的内部图像是由抗独特型反应产生的。从3例患者血清中分离的抗独特型抗体显示出明显的交叉反应性。产生抗独特型抗体的患者临床症状得到改善，病情长期缓解。人免疫球蛋白分子上可能存在的癌抗原的内部图像可能改变免疫系统对肿瘤抗原反应的条件，并可能开辟控制肿瘤生长的新方法。
Inoculation of human subjects with mouse monoclonal antibody results in the production of anti-idiotype antibody that reacts with the binding site of the monoclonal antibody. This reaction is hapten-inhibited, suggesting that an internal image of the antigen is produced by the anti-idiotype response. The anti-idiotype antibody isolated from sera of three patients showed significant crossreactivity. Patients who developed the anti-idiotype antibody improved clinically and had long remission from their disease. The possible presence of the internal image of cancer antigen on the human immunoglobulin molecule may change the conditions under which the immune system reacts to the tumor antigen and may open new approaches to the control of tumor growth.