Human Papillomavirus Positivity in Women Undergoing Intrauterine Insemination Has a Negative Effect on Pregnancy Rates
Human Papillomavirus Positivity in Women Undergoing Intrauterine Insemination Has a Negative Effect on Pregnancy Rates
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DOI：
10.1159/000434749
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发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Bosmans, Eugene
中科院分区：
文献类型：
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作者：
Depuydt, Christophe E.;Verstraete, Ludo;Bosmans, Eugene
背景：性传播感染是不孕症的主要原因。人乳头瘤病毒（HPV）感染是女性生殖道最常见的病毒感染之一。只有有限数量的研究调查了HPV对生育的影响，其影响仍然存在争议。目的：探讨宫颈HPV感染与宫内人工授精（IUD）后妊娠结局的关系。由于其他性传播感染也可能影响妊娠结局，我们还分析了阴道毛滴虫（TV）和沙眼衣原体（CT）对妊娠结局的影响。方法：我们对2010年至2014年期间在AML中接受1，529个IUI周期的590名女性进行了回顾性分析。采用PCR方法检测宫颈细胞学标本中18种不同类型HPV（6、11、16、18、31、33、35、39、45、51、52、53、56、58、59、66、67、68）和TV的阳性率。CT状态通过检测血清样本上的伊加/IgG抗体或通过PCR检测宫颈拭子来确定。结果：每个IUI周期的HPV患病率为11.0%，CT为6.9%;没有妇女的TV检测呈阳性。IUI后，HPV阳性女性怀孕的可能性降低了六倍（1.87%比11.36%; p = 0.0041）。有或无CT病史的妇女的妊娠率无显著差异（8.51 vs. 11.10%; p >0.05）。结论：HPV检测与阴性IUI结局相关。(C)2015 S. Karger AG，巴塞尔
Background: Sexually transmitted infections are a major cause of infertility. Human papillomavirus (HPV) infection is one of the most common viral infections of the female genital tract. Only a limited number of studies have investigated the influence of HPV on fertility and its impact remains controversial. Objective: We investigated the relationship between cervical HPV infection and pregnancy outcome after intrauterine insemination (IUD. Since other sexually transmitted infections could also influence outcome, we also analyzed the influence of Trichomonas vaginalis (TV) and Chlamydia trachomatis (CT) on pregnancy outcome. Methods: We performed a retrospective analysis of 590 women who underwent 1,529 IUI cycles at AML between 2010 and 2014. Positivity of 18 different HPV types (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68) and TV was assessed by PCR in cervical cytology specimens. CT status was ascertained by detection of IgA/IgG antibodies on serum samples or by PCR on cervical swabs. Results:The HPV prevalence per IUI cycle was 11.0 and 6.9% for CT; none of the women tested positive for TV. HPV-positive women were six times less likely to become pregnant after IUI (1.87 vs. 11.36%; p = 0.0041). There was no significant difference in pregnancy rates between women with or without a history of CT (8.51 vs. 11.10%; p >0.05). Conclusion: Detection of HPV is associated with a negative IUI outcome. (C) 2015 S. Karger AG, Basel