Confirmation of an association between family history of affective disorder and the depressive syndrome in Alzheimer's disease.
Confirmation of an association between family history of affective disorder and the depressive syndrome in Alzheimer's disease.
复制标题
证实情感障碍家族史与阿尔茨海默氏病抑郁综合征之间的关联。
DOI：
10.1176/ajp.153.10.1340
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Ogrocki,PK
中科院分区：
文献类型：
--
作者：
Strauss,ME;Ogrocki,PK
作者的目标是复制早期发现的抑郁症在Alzheimer's disease.MethodThe抑郁症和痴呆症的家族史进行了比较，在28例患者经历了第一次发作的抑郁症后，阿尔茨海默氏病和74 nondepressed患者与Alzheimer's disease.ResultsSignificantly更多的家庭抑郁症痴呆症患者包括抑郁症的一级亲属。有和没有抑郁症的阿尔茨海默氏病患者之间没有差异的比例，有痴呆症的历史。ConclusionsMajor抑郁症的阿尔茨海默氏病与抑郁症的家庭责任是独立的任何痴呆症的家庭责任。
ObjectiveThe authors' goal was to replicate an earlier finding of a familial liability for depression in Alzheimer's disease.MethodThe family histories of depression and dementia were compared in 28 patients experiencing a first episode of major depression after onset of Alzheimer's disease and 74 nondepressed patients with Alzheimer's disease.ResultsSignificantly more families of depressed dementia patients included depressed first-degree relatives. There was no difference between Alzheimer's disease patients with and without depression in the proportion of families with a history of dementia.ConclusionsMajor depression in Alzheimer's disease is associated with a familial liability for depression that is independent of any familial liability for dementia.