PREVENTION OF EXPERIMENTAL ORAL-CANCER BY EXTRACTS OF SPIRULINA-DUNALIELLA ALGAE
PREVENTION OF EXPERIMENTAL ORAL-CANCER BY EXTRACTS OF SPIRULINA-DUNALIELLA ALGAE
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DOI：
10.1080/01635588809513979
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发表时间：
1988-01-01
影响因子：
2.9
通讯作者：
TRICKLER, D
中科院分区：
文献类型：
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作者：
SCHWARTZ, J;SHKLAR, G;TRICKLER, D
螺旋藻-杜氏藻的提取物显示，当在矿物油中局部应用0.1%的7，12-二甲基苯并[a]蒽（DMBA）溶液时，每周三次，持续28周，可以预防仓鼠颊囊中的肿瘤发展。藻类提取物以140 μ g/0.4ml矿物油的连续剂量每周三次经口递送。28周后，给予赋形剂和未处理对照的动物均出现右颊囊的大体肿瘤。喂食β-胡萝卜素的动物表现出肿瘤数量和大小的较小但具有统计学显著性的减少。藻类动物完全没有肉眼可见的肿瘤。然而，藻类组的颊囊显微切片显示局部发育不良区域和早期原位癌正在遭受破坏。
An extract of Spirulina‐Dunaliella algae was shown to prevent tumor development in hamster buccal pouch when a 0.1% solution of 7, 12‐dimethylbenz[a]anthracene (DMBA) in mineral oil was applied topically three times weekly for 28 weeks. The algae extract was delivered by mouth in continued dosages of 140 jig in 0.4 ml mineral oil three times per week. After 28 weeks, the animals given vehicle and untreated controls all presented gross tumors of the right buccal pouch.Animals fed canthaxanthin presented a notably and statistically significant reduction in tumor number and size compared with controls. Animals fed β‐carotene demonstrated a smaller but statistically significant reduction in tumor number and size. The algae animals presented a complete absence of gross tumors. However, microscopic sections of the buccal pouch in the algae group showed localized areas of dysplasia and early carcinoma‐in‐situ undergoing destruction.