The Cytoskeleton Coordinates the Early Events of B-cell Activation
The Cytoskeleton Coordinates the Early Events of B-cell Activation
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DOI：
10.1101/cshperspect.a002360
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发表时间：
2011-02-01
影响因子：
7.2
通讯作者：
Batista, Facundo D.
中科院分区：
文献类型：
--
作者：
Harwood, Naomi E.;Batista, Facundo D.
B 细胞受体 (BCR) 与特定抗原结合后，通过产生抗体和长寿命记忆细胞，B 细胞有助于保护性适应性免疫反应。最近的成像研究为 B 细胞激活的后续分子和细胞事件提供了新的见解。与抗原结合后，BCR 微簇形成并通过招募细胞内信号分子和接头作为活性信号传导位点。通过这些“微信号体”的信号通过 B 细胞以 CD19 依赖性方式扩散来传播和增强。随后，形成成熟的免疫突触，并作为抗原内化的平台，使抗原呈递给最大 B 细胞激活所需的辅助 T 细胞。在这篇综述中，我们讨论了细胞骨架在 B 细胞激活过程中这些分子事件的协调和调节中新兴的关键作用。
B cells contribute to protective adaptive immune responses through generation of antibodies and long-lived memory cells, following engagement of the B-cell receptor (BCR) with specific antigen. Recent imaging investigations have offered novel insights into the ensuing molecular and cellular events underlying B-cell activation. Following engagement with antigen, BCR microclusters form and act as sites of active signaling through the recruitment of intracellular signaling molecules and adaptors. Signaling through these "microsignalosomes" is propagated and enhanced through B-cell spreading in a CD19-dependent manner. Subsequently, the mature immunological synapse is formed, and functions as a platform for antigen internalization, enabling the antigen presentation to helper T cells required for maximal B-cell activation. In this review, we discuss the emerging and critical role for the cytoskeleton in the coordination and regulation of these molecular events during B-cell activation.