Brief Report: Circulating Markers of Immunologic Activity Reflect Adiposity in Persons With HIV on Antiretroviral Therapy.
Brief Report: Circulating Markers of Immunologic Activity Reflect Adiposity in Persons With HIV on Antiretroviral Therapy.
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DOI：
10.1097/qai.0000000000001768
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发表时间：
2018-09-01
期刊：
影响因子：
--
通讯作者：
Kalams SA
中科院分区：
文献类型：
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作者：
Koethe JR;Jenkins CA;Furch BD;Lake JE;Barnett L;Hager CC;Smith R;Hulgan T;Shepherd BE;Kalams SA
肥胖改变了脂肪组织免疫学，这些变化可能反映在HIV研究中测量的循环可溶性炎症生物标志物和T细胞亚群谱中。我们招募了70名接受依法韦仑、替诺福韦和恩曲他滨治疗的HIV成人（50%肥胖），病毒学抑制>2年，无风湿性或其他已知炎症性疾病。我们测量了几种先天免疫标志物和主要CD 4+和CD 8 + T细胞亚群的空腹血浆水平。我们使用协变量校正的斯皮尔曼等级相关性评估了总肥胖测量值（体重指数[BMI]、DEXA脂肪质量指数[FMI]和血浆瘦素）与免疫学参数之间的关系。该队列为43%女性，54%非白人，中位年龄为45岁。较高的BMI、FMI和血浆瘦素始终与较高的C反应蛋白、血清淀粉样蛋白A和白细胞介素（IL）-6相关（所有p<0.01），但与较低的IL-10相关（所有p≤0.02）。BMI和FMI与可溶性肿瘤坏死因子-α受体1水平呈正相关（两者均为p<0.02），所有三种身体成分测量值与可溶性CD 163的正相关性接近显著性（均为p≤0.09）。BMI和FMI越高，CD 4 + T细胞上的CD 38表达越低（两者p≤0.04），但CD 69表达越高（BMI和FMI p≤0.01，瘦素p=0.07）。更大的肥胖与有限的循环免疫标志物的改变有关，可能反映了已知在治疗HIV感染的脂肪组织中发生的变化。与BMI相比，X线测量总脂肪量并没有产生实质性的不同结果。
Obesity alters adipose tissue immunology, and these changes may be reflected in circulating soluble inflammatory biomarker and T cell subset profiles measured in HIV research studies. We recruited 70 adults with HIV (50% obese) on efavirenz, tenofovir, and emtricitabine, virologic suppression for >2 years, and no rheumatologic or other known inflammatory conditions. We measured fasting plasma levels of several markers of innate immunity and major CD4+ and CD8+ T cell subsets. We assessed relationships between measurements of total adiposity (body mass index [BMI], DEXA fat mass index [FMI], and plasma leptin) and the immunologic parameters using covariate-adjusted Spearman’s rank correlations. The cohort was 43% female, 54% non-white, and median age was 45 years. Higher BMI, FMI and plasma leptin were consistently associated with higher C-reactive protein, serum amyloid A, and interleukin (IL)-6 (p<0.01 for all), but lower IL-10 (p≤0.02 for all). BMI and FMI were positively associated with soluble tumor necrosis factor-α receptor 1 levels (p<0.02 for both), and a positive correlation approached significance for all three body composition measurements with soluble CD163 (p≤0.09 for all). Higher BMI and FMI were associated with lower CD38 expression on CD4+ T cells (p≤0.04 for both), but higher CD69 expression (p≤0.01 for BMI and FMI, p=0.07 for leptin). Greater adiposity is associated with alterations in a limited set of circulating immune markers, potentially reflecting changes known to occur in adipose tissue with treated HIV infection. Measuring total fat mass radiographically did not yield substantively different results compared to BMI.