A STATISTICAL NOTE ON CEREBELLAR AND BRAIN‐STEM WEIGHT IN MONGOLISM
A STATISTICAL NOTE ON CEREBELLAR AND BRAIN‐STEM WEIGHT IN MONGOLISM
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蒙古族小脑和脑干重量的统计记录
DOI：
10.1111/j.1365-2788.1966.tb00173.x
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发表时间：
2008
影响因子：
3.6
通讯作者：
E. Slater
中科院分区：
文献类型：
--
作者：
L. Crome;V. Cowie;E. Slater
方法与结果 1 脑总重和总脑重。干细胞和小脑取自方田集团医院 19 例蒙古病患者的尸检（表 1）。将这些数据与 Krogman (1941) 报告的克雷曼儿童从出生到 14 岁的值进行比较，匹配年龄和性别，并将这些值作为正常注射的标准。观察到的体重与预期体重的比率显示总脑重量和 di 均减少。脑干和小脑的重量按比例更极端地减少。尽管整个大脑的重量平均减少至正常重量的 76%，但脑干和小脑的重量平均低于正常重量的 6%。 10% 的差异在统计上具有高度显着性。在个体内部，这两个权重是相互关联的。大约 19 年中的 17 年。在这些情况下，全脑的观察与期望的比率高于脑干和小脑的观察与期望的比率，并且只有两种情况{Nos. 11 和 17）则相反。这两个比率在个体中的平均差异为10.2%±2.3%，其中t^4.43，p<.()01（参见表2）。因此，小脑和脑干尺寸的不成比例缩小可能是蒙古人的一个特殊特征。另一种看待数据的方式并非没有兴趣。参考克罗格曼的表格可以看出，在他引用的美国标准中，小脑和脑干的总重量在1岁之后所占的比例始终为12%。出生时该比例为 7.3%，3 个月时为 7.9%，9 个月时为 11.0%，1 岁时为 11.5%。从数据来看。根据 Cierman 儿童的数据，我们可以计算出男孩的这一比例为 12.48%，女孩为 12.97%，这两个数字彼此之间没有显着差异，并且从一岁起，两者在年龄方面都保持不变。两性的平均毛皮率为 12.7%，标准差为 1.1%。表一显示了我们 19 个案例中每个案例的百分比。他会的；可以看出，除了两种情况外，在所有情况下该值都小于
METHOD AND RESULTS 1 he total brain weight and the weight of ttir brain-. stem and cerebellum were obtained from the post-mortem examinations of 19 patients with mongolism in the Fountain Group of Hospitals {Table 1). These were compared, matching for age and sex, with the values reported by Krogman (1941) for Crerman children from birth to 14 years, taking these as a standard for normal sul) jects. The ratio of observed to expected weights showed both a diminution of the total brain weiglit and a di. sproportionately more extreme diminution of the weight of brain-stem and cerebellum, taken together. Whereas tbe brain as a whole was reduced on average to 76% of its normal weight, the weight of brain-stem and cerebellum was on average less tban f> 6% of normal. Tins difference of 10% is highly significant statistically. Within individuals the two weights are correlated with one another; in 17 out of the 19 ca. ses the ratio of observation to expectation was higher for total brain than for brain-stem and cerebellum, and in only two cases {Nos. 11 and 17) was the opposite true. The mean difference between these two ratios witliin individuals was 10.2%±2.3%, for which t^ 4.43, p<.() 01 {see Table 2). It appears, therefijre, that a disproportionate reduction in the size of the cerebellum and brain-stem may be a specific feature of mongulisni. Another way of looking at the data is not without interest. Reference to Krogman's tables shows that, in tlif American standards he quotes, the proportion of the total brain weight made up by the combined weight of cerebellum and brainstem is very constantly 12% after the age of 1 year. At birth the proportion is 7.3%, at 3 months 7.9%, at 9 months 11.0% and at 1 year 11.5%. From the data. supplied about Cierman children, we can calculate the proportion as 12.48% in boys and 12.97% in girls, these two figures not differing significantly from one another, and both)) eing invariant in respect of age from one year onwards. The mean fur both sexes is 12.7%, and the standard deviation 1.1%. Table I shows the percentage in each of our 19 cases. It will he s; een that in all but two cases the value is less than