Atrophic dermatofibrosarcoma protuberans: Case report, review, and proposed molecular mechanisms
Atrophic dermatofibrosarcoma protuberans: Case report, review, and proposed molecular mechanisms
复制标题
DOI：
10.1067/s0190-9622(03)00793-x
复制
发表时间：
2003-10-01
影响因子：
13.8
通讯作者：
Albertini, JG
中科院分区：
文献类型：
--
作者：
Young, RJ;Albertini, JG
我们报告一例萎缩性隆突性皮肤纤维肉瘤，这是一种罕见的临床变异。我们讨论了隆突性皮肤纤维肉瘤发生的分子和遗传学机制，回顾了有关萎缩性隆突性皮肤纤维肉瘤的文献，并提出了该萎缩变异体的表型的分子机制。我们还描述了在冰冻切片上使用Mohs显微图像切除和CD34免疫染色来明确治疗肿瘤。
We report a case of atrophic dermatofibrosarcoma protuberans, an uncommon clinical variant. We discuss molecular and genetic mechanisms of dermatofibrosarcoma protuberans tumorigenesis, review the literature on atrophic dermatofibrosarcoma protuberans, and pose a molecular mechanism for the atrophic variant's phenotype. We also describe using Mohs micrographic excision with CD34 immunostains on the frozen sections to definitively treat the tumor.