Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: a systematic review and meta-analysis.
Effect of supplementation with rebamipide for Helicobacter pylori eradication therapy: a systematic review and meta-analysis.
复制标题
补充瑞巴派特对幽门螺杆菌根除治疗的效果：系统评价和荟萃分析。
DOI：
10.1111/jgh.12769
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Nishizawa;T.;Nishizawa;Y.;Yahagi;N.;Kanai;T.;Takahashi;M.;Suzuki;H.
背景与目的多项研究报道在根除幽门螺杆菌过程中应用瑞巴派特可提高根除率。然而，其有效性和安全性存在争议。本研究通过基于随机对照试验（RCTs）的Meta分析系统评价瑞巴派特是否能提高幽门螺杆菌的根除率。方法在以下数据库中进行文献检索：PubMed、科克伦图书馆和日本Igaku-chuo-zasshi数据库。对所有比较瑞巴派特补充与不含瑞巴派特治疗的RCT进行Meta分析。ResultsWe确定了6项随机试验（611例患者）。通过符合方案分析，使用或不使用瑞巴派特的患者的合并幽门螺杆菌根除率分别为73.3%和61.4%。优势比为1.74（95%置信区间）。1.19-2.53).结论补充瑞巴派特可能有效提高质子泵转运蛋白-阿莫西林双重治疗的幽门螺杆菌根除率。
Background and AimSeveral studies have reported that the application of rebamipide during the eradication ofHelicobacter pylorican improve the eradication rate. However, the efficacy and safety are controversial. The present study systematically evaluated whether rebamipide improves the eradication rate ofH. pyloriby conducting a meta‐analysis based on randomized controlled trials (RCTs).MethodsLiterature searches were conducted in the following database: PubMed, the Cochrane Library, and the Igaku‐chuo‐zasshi database in Japan. A meta‐analysis of all RCTs comparing rebamipide supplementation with non‐rebamipide‐containing therapy was performed.ResultsWe identified six randomized trials (611 patients). PooledH. pylorieradication rates by per‐protocol analysis were 73.3% and 61.4% for patients with or without rebamipide, respectively. The odds ratio was 1.74 (95% confidence interval. 1.19–2.53).ConclusionsSupplementation with rebamipide might be effective in increasing theH. pylorieradication rates of proton‐pump inhibitor–amoxicillin dual therapy.