Gene annotation bias impedes biomedical research

Gene annotation bias impedes biomedical research
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DOI:
10.1038/s41598-018-19333-x
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发表时间:
2018-01-22
期刊:
影响因子:
4.6
通讯作者:
Khatri, Purvesh
Khatri, Purvesh
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Haynes, Winston A.;Tomczak, Aurelie;Khatri, Purvesh

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我们发现基因和蛋白质注释资源之间存在巨大的差异。我们观察到,这种偏见导致生物医学研究人员将重点放在注释丰富的基因上,而不是那些拥有最强分子数据的基因上。我们主张研究人员通过追求数据驱动的假设来减少这些偏见。
We found tremendous inequality across gene and protein annotation resources. We observed that this bias leads biomedical researchers to focus on richly annotated genes instead of those with the strongest molecular data. We advocate that researchers reduce these biases by pursuing data-driven hypotheses.