Enrico Coen
Enrico Coen
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恩里科·科恩
DOI：
10.1016/j.cub.2023.09.026
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发表时间：
2023
期刊：
影响因子：
9.2
通讯作者：
Coen E
中科院分区：
文献类型：
--
作者：
Coen E
是什么吸引你到你的特定研究领域？1979年从遗传学专业毕业后，我在剑桥攻读了果蝇基因组进化的博士学位。我对研究产生了热情，但也意识到科学家并不像我想象的那样客观：他们可能会对想法产生依恋，并排斥那些不同意他们的人。我希望，也许我能找到一个不受这种态度影响的模糊研究领域。我申请了一项研究金，以分离一种众所周知但研究不足的发育和进化特征的基因：报春花的异形自交不亲和性。在当时的技术条件下，这被证明是一个棘手的问题花了30年的时间才克隆出这些基因，但这项工作引发了我对植物遗传学的终身兴趣。在我获得奖学金一年左右的时间里，约翰·英尼斯中心（John Innes Centre）出现了一个研究金鱼草转座子的职位。在接下来的几年里，我与经验丰富的金鱼草遗传学家迷迭香·卡彭特（Rosemary Carpenter）合作，分离并克隆了几个发育基因，使我进入了主流植物研究领域。我找到了一个不受个人态度束缚的研究领域吗？不，我开始意识到科学是一种人类活动，它带来了所有的激情和缺点，包括我自己的。
What drew you to your specific field of research? After graduating in genetics in 1979, I did a PhD on Drosophila genome evolution in Cambridge. I developed a passion for research but also realised that scientists were not as objective as I had imagined: they could become attached to ideas and disparage those who disagreed with them. I hoped that perhaps I could find an obscure research area free from such attitudes. I applied for a fellowship to isolate genes underlying a wellknown but understudied developmental and evolutionary trait: heteromorphic self-incompatibility in primroses. This proved an intractable problem with the technology available then—it took 30 years before the genes could be cloned—but the work started my lifelong interest in plant genetics. A year or so into my fellowship, a position came up at the John Innes Centre to study transposons in snapdragons. Over the next few years I worked with Rosemary Carpenter, an experienced snapdragon geneticist, to isolate and characterise several developmental genes, taking me into mainstream plant research. Did I find a research field untrammelled by personal attitudes? No, I came to realise that science is a human activity with all the passions and foibles that this brings, including my own.