Regulation of adaptive immunity; the role of interleukin-10.
Regulation of adaptive immunity; the role of interleukin-10.
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DOI：
10.3389/fimmu.2013.00129
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发表时间：
2013
影响因子：
7.3
通讯作者：
Wraith DC
中科院分区：
文献类型：
--
作者：
Ng TH;Britton GJ;Hill EV;Verhagen J;Burton BR;Wraith DC
自从20世纪80年代发现白介素10(IL-10)以来，大量的工作使人们认识到它是一种多效性免疫调节细胞因子，既影响先天性免疫系统，也影响获得性免疫系统。IL-10是由多种细胞类型产生的，但为了这篇综述的目的，我们将重点放在由CD4+T细胞分泌的IL-10。在这里，我们描述了IL-10作为FoxP3+和FoxP3−T调节细胞所使用的抑制的中介的重要性。此外，我们还讨论了导致T辅助细胞亚群分泌IL-10的分子事件，在T辅助细胞亚群中，IL-10是一个关键的负反馈机制。最后，我们讨论如何更好地理解这一原理，从而设计出更有效的、抗原特异性的免疫治疗策略，以便在临床上利用这一自然现象。
Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and adaptive immune systems. IL-10 is produced by a wide range of cell types, but for the purposes of this review we shall focus on IL-10 secreted by CD4+ T cells. Here we describe the importance of IL-10 as a mediator of suppression used by both FoxP3+ and FoxP3− T regulatory cells. Moreover, we discuss the molecular events leading to the induction of IL-10 secretion in T helper cell subsets, where it acts as a pivotal negative feedback mechanism. Finally we discuss how a greater understanding of this principle has allowed for the design of more efficient, antigen-specific immunotherapy strategies to exploit this natural phenomenon clinically.