Internal Pair Production of 90Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept
Internal Pair Production of 90Y Permits Hepatic Localization of Microspheres Using Routine PET: Proof of Concept
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DOI：
10.2967/jnumed.110.080986
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发表时间：
2011-01-01
影响因子：
9.3
通讯作者：
Salem, Riad
中科院分区：
文献类型：
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作者：
Gates, Vanessa L.;Esmail, Abdulredha A. H.;Salem, Riad
Y-90微球放射栓塞是一种新的经动脉放射治疗肝肿瘤。本初步研究的目的是评价Y-90玻璃微球植入后PET/CT的结果。研究方法：3例肝细胞癌患者和2例肝转移瘤患者（1例神经内分泌癌，1例结直肠癌）在放射性栓塞后接受了PET/CT检查。4例患者在1个月时接受了成像，以评估反应并确认PET/CT结果; 1例患者在Y-90植入后4天接受了PET/CT。对患者进行不良事件随访。结果：标准PET/CT能够对所有患者进行Y-90玻璃微球定位。没有患者发生与非靶向沉积相关的不良事件。结论：标准PET/CT可用于评价Y-90玻璃微球的定位。这种方法提供了一种简单、快速和普遍适用的确认微球沉积的方法。通过进一步验证，该技术可能成为确认微球分布的标准护理。
Radioembolization with Y-90 microspheres represents a novel transarterial radiation treatment for liver tumors. The purpose of this pilot study was to evaluate the findings of postimplantation PET/CT of Y-90 glass microspheres. Methods: Three patients with hepatocellular carcinoma and 2 patients with liver metastases (1 neuroendocrine, 1 colorectal) underwent PET/CT after radioembolization. Four patients underwent imaging at 1 mo to assess response and confirm PET/CT findings; 1 patient underwent PET/CT at 4 d after Y-90 implantation. Patients were followed for adverse events. Results: Standard PET/CT enabled the localization of Y-90 glass microspheres for all patients. None of the patients experienced adverse events related to nontarget deposition. Conclusion: Standard PET/CT may be used to assess the localization of Y-90 glass microspheres. This approach provides a simple, rapid, and universally applicable method of confirming microsphere deposition. With further validation, this technique may potentially become the standard of care for confirming microsphere distribution.