Yin and Yang: The dual effects of interferons on hematopoiesis.
Yin and Yang: The dual effects of interferons on hematopoiesis.
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DOI：
10.1016/j.exphem.2021.02.002
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发表时间：
2021-04
影响因子：
2.6
通讯作者：
King KY
中科院分区：
文献类型：
--
作者：
Demerdash Y;Kain B;Essers MAG;King KY
Interferons are an ancient and well-conserved group of inflammatory cytokines most famous for their role in viral immunity. A decade ago, we discovered that interferons also play an important role in the biology of hematopoietic stem cells (HSCs), which are responsible for lifelong blood production. Though we have learned a great deal about the role of interferons on HSC quiescence, differentiation, and self-renewal, there remains some controversy regarding how interferons impact these stem cells, with differing conclusions depending on experimental models and clinical context. Here, we review the contradictory roles of Type 1 and 2 interferons in hematopoiesis. Specifically, we highlight the roles of interferons in embryonic and adult hematopoiesis, along with short-term and long-term adaptive and maladaptive responses to inflammation. We discuss experimental challenges in the study of these powerful yet short-lived cytokines and strategies to address those challenges. We further review the contribution by interferons to disease states including bone marrow failure and aplastic anemia as well as their therapeutic use to treat myeloproliferative neoplasms and viral infections, including SARS-CoV2. Understanding the opposing effects of interferons on hematopoiesis will elucidate immune responses and bone marrow failure syndromes, and future therapeutic approaches for patients undergoing HSC transplantation or fighting infectious diseases and cancer.
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DOI：
10.1056/nejmoa1409405
发表时间：
2014-12-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Genovese G;Kähler AK;Handsaker RE;Lindberg J;Rose SA;Bakhoum SF;Chambert K;Mick E;Neale BM;Fromer M;Purcell SM;Svantesson O;Landén M;Höglund M;Lehmann S;Gabriel SB;Moran JL;Lander ES;Sullivan PF;Sklar P;Grönberg H;Hultman CM;McCarroll SA
通讯作者：
McCarroll SA
影响因子：
6.7
作者：
Belyaev NN;Biró J;Langhorne J;Potocnik AJ
通讯作者：
Potocnik AJ
影响因子：
20.3
作者：
de Bruin, Alexander M.;Libregts, Sten F.;Nolte, Martijn A.
通讯作者：
Nolte, Martijn A.
影响因子：
4.3
作者：
Kaschutnig, Paul;Bogeska, Ruzhica;Milsom, Michael D.
通讯作者：
Milsom, Michael D.
影响因子：
0.6
作者：
Bohn, Jan-Paul;Gastl, Guenther;Steurer, Michael
通讯作者：
Steurer, Michael