Decline of anti-desmoglein 1 IgG ELISA scores by withdrawal of D-penicillamine in drug-induced pemphigus foliaceus
Decline of anti-desmoglein 1 IgG ELISA scores by withdrawal of D-penicillamine in drug-induced pemphigus foliaceus
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DOI：
10.1111/j.1365-2230.2004.01655.x
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发表时间：
2005-01-01
影响因子：
4.1
通讯作者：
Amagai, M
中科院分区：
文献类型：
--
作者：
Nagao, K;Tanikawa, A;Amagai, M
报告了一例在服用d -青霉胺期间引起的叶状天疱疮。一名72岁的系统性硬化症妇女在服用d -青霉胺1年后出现皮肤松弛性囊泡和结痂性红斑。ELISA检测抗粘粒蛋白1 IgG阳性。d -青霉胺的停用导致皮肤病变的改善，抗demoglein 1抗体的ELISA评分显示惊人的快速下降。本病例为典型的药物性叶状天疱疮，在该病例中，d -青霉胺不仅需要诱导，而且需要维持自身抗体的产生。
A case of pemphigus foliaceus arising during the administration of D-penicillamine was reported. A 72-year-old woman with systemic sclerosis developed flaccid vesicles and crusted erythema of the skin after administration of D-penicillamine for 1-year. She was positive for anti-desmoglein 1 IgG by ELISA. The withdrawal of D-penicillamine resulted in improvement of the skin lesions and ELISA scores for anti-demoglein 1 antibodies revealed a surprisingly rapid decline. This case is a classical incidence of drug-induced pemphigus foliaceus, in which D-penicillamine was constantly required not only to induce, but also to maintain the production of the autoantibodies.