Urinary α1-microglobulin as a marker of nephropathy in type 2 diabetlic Asian subiects in Singapore
Urinary α1-microglobulin as a marker of nephropathy in type 2 diabetlic Asian subiects in Singapore
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DOI：
10.2337/diacare.26.2.338
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发表时间：
2003-02-01
期刊：
影响因子：
16.2
通讯作者：
Ling, SL
中科院分区：
文献类型：
--
作者：
Hong, CY;Hughes, K;Ling, SL
目的-本研究探讨尿α（1）-微球蛋白作为早期肾病的标志物在2型糖尿病中国人，马来人，和亚洲印度人在新加坡.研究设计和方法-一个横断面研究进行了590个连续的2型糖尿病患者（296名男性，294名女性）谁是在初级保健诊所的常规后续行动。信息来自访谈、病例记录、血液和尿液样本。由于尿α（1）-微球蛋白水平的分布高度偏态，因此对这些水平进行对数转换，并计算几何平均值。通过除以尿肌酐水平（以mg/mmol尿肌酐表示）校正尿流量的变异性，并校正混杂变量。结果-尿α 1-微球蛋白男性高于女性，与年龄直接相关，但种族差异不明显。它与糖尿病的持续时间直接相关，校正的几何平均值为1.19和1.43 mg/mmol尿肌酐，持续时间为
OBJECTIVE - This study examines urinary alpha(1)-microglobulin as a marker of early nephropathy in type 2 diabetic Chinese, Malays, and Asian Indians in Singapore.RESEARCH DESIGN AND METHODS - A cross-sectional study was performed on 590 consecutive type 2 diabetic patients (296 males, 294 females) who were on routine follow-up at a primary care clinic. Information was obtained from interviews, case notes, and blood and urine samples. Because the distribution of urinary alpha(1)-microglobulin levels was highly skewed, these levels were log-transformed, and geometric means were calculated. There was correction for variability in urine flow by dividing by urine creatinine levels, given as mg/mmol urine creatinine, and adjustment for confounding variables.RESULTS - Urinary alpha(1)-microglobulin was higher in men than in women and was directly related to age, but no ethnic differences were apparent. It was directly related to duration of diabetes, with adjusted geometric means of 1.19 and 1.43 mg/mmol urine creatinine for a duration of